Immunoglobulin GM and KM allotypes and antibody responses to Epstein-Barr virus antigens.
Immunoglobulin GM and KM allotypes and antibody responses to Epstein-Barr virus antigens.
复制标题
免疫球蛋白 GM 和 KM 同种异型以及对 Epstein-Barr 病毒抗原的抗体反应。
DOI：
10.1086/605019
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Pandey,JanardanP
中科院分区：
文献类型：
--
作者：
Pandey,JanardanP
To the Editor—Besson et al [1], in their study of first-degree relatives from families with Epstein-Barr virus (EBV)–related lymphomas, provide strong evidence for polygenic inheritance of the ability to generate antibodies to the EBV viral capsid antigen (VCA), and they conclude that these results “pave the way for identification of the loci involved”[1, p 1121]. I would like to draw attention to a 25-year-old study that suggested that immunoglobulin loci are involved in antibody responsiveness to several EBV antigensIn 1984, a study by Biggar et al [2] showed that immunoglobulin GM and KM allotypes—genetic markers of γ and κ light chains, respectively—interact in a complex manner to influence the antibody responses to EBV antigens. My colleagues and I showed that, in patients with Burkitt lymphoma, simultaneous homozygosity or heterozygosity at GM (chromosome 14) and KM (chromosome 2) loci resulted in higher antibody responses to EBV antigens than did dissimilar zygosity at the 2 loci. These results—coupled with the substantial heritability for anti-VCA immunoglobulin G (IgG) antibodies reported by Besson et al [1]—provide a strong rationale for large-scale studies to examine the role played by immunoglobulin GM and KM genes in humoral immunity to EBV antigens. Such studies must include diverse population groups, because major races are characterized by unique arrays of GM haplotypes and because KM gene frequencies also vary significantly among various groups [3]—therefore, associations obtained in one racial group may not be transferable to another group
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