Mitochondrial fission in hepatocytes as a potential therapeutic target for nonalcoholic steatohepatitis
Mitochondrial fission in hepatocytes as a potential therapeutic target for nonalcoholic steatohepatitis
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DOI：
10.1111/hepr.13832
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发表时间：
2022-08
影响因子：
4.2
通讯作者：
Masashi Miyao;C. Kawai;H. Kotani;Hirozo Minami;H. Abiru;H. Hamayasu;Satoru Eguchi;Keiji Tamaki
中科院分区：
文献类型：
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作者：
Masashi Miyao;C. Kawai;H. Kotani;Hirozo Minami;H. Abiru;H. Hamayasu;Satoru Eguchi;Keiji Tamaki
线粒体是高度可塑性和动态的细胞器；据报道，线粒体功能障碍在糖尿病、心血管疾病和非酒精性脂肪性肝病(NAFLD)中起致病作用。然而，线粒体分裂与NAFLD发病机制的关系尚不清楚。我们的目的是研究线粒体分裂的改变是否在NAFLD的进展中起作用。
The mitochondria are highly plastic and dynamic organelles; mitochondrial dysfunction has been reported to play causative roles in diabetes, cardiovascular diseases, and nonalcoholic fatty liver disease (NAFLD). However, the relationship between mitochondrial fission and NAFLD pathogenesis remains unknown. We aimed to investigate whether alterations in mitochondrial fission could play a role in the progression of NAFLD.