Secondary metabolites isolated from the deep sea-derived fungus Aspergillus sydowii C1-S01-A7
Secondary metabolites isolated from the deep sea-derived fungus Aspergillus sydowii C1-S01-A7
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DOI：
10.1080/14786419.2018.1519561
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发表时间：
2018-09
影响因子：
2.2
通讯作者：
Weiyi Wang;Maolin Gao;Zhuhua Luo;Yanyan Liao;Beibei Zhang;Wenqian Ke;Z. Shao;Fang Li;Jianming Chen
中科院分区：
文献类型：
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作者：
Weiyi Wang;Maolin Gao;Zhuhua Luo;Yanyan Liao;Beibei Zhang;Wenqian Ke;Z. Shao;Fang Li;Jianming Chen
摘要从深海源真菌西多曲霉C1-S01-A7的培养物中获得了2-羟基-6-甲酰基-垂直蒽酮(1)和12- o -乙酰基- sydowwinin A(2)两个新化合物，以及22个已知化合物（3-24）。利用广谱分析方法对它们的结构进行了分析。化合物4、8和12对轮状弧菌和创伤弧菌具有抑菌活性。化合物1、2、7、8、11和12对耐甲氧西林金黄色葡萄球菌具有抗菌活性。值得注意的是，与其他化合物相比，化合物8对A549具有选择性的细胞毒活性，对A549和HepG2具有最强的细胞毒活性。
Abstract Two novel compounds, 2-hydroxy-6-formyl-vertixanthone (1) and 12-O-acetyl-sydowinin A (2), were obtained from the culture of a deep sea-derived fungus Aspergillus sydowii C1-S01-A7, together with twenty-two known compounds (3–24). Their structures were elucidated based on extensive spectroscopic methods. Compounds 4, 8 and 12 showed antibacterial activities against Vibrio rotiferianus and Vibrio vulnificus. Compounds 1, 2, 7, 8, 11 and 12 exhibited antibacterial activity against methicillin-resistant Staphylococcus aureus. Remarkably, compound 8 displayed selectively cytotoxic activity against A549 and strongest cytotoxic activities for both A549 and HepG2 in comparison to the remaining compounds.