Functional Dissociation in Right Inferior Frontal Cortex during Performance of Go/No-Go Task
Functional Dissociation in Right Inferior Frontal Cortex during Performance of Go/No-Go Task
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DOI：
10.1093/cercor/bhn065
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发表时间：
2009-01-01
期刊：
影响因子：
3.7
通讯作者：
Konishi, Seiki
中科院分区：
文献类型：
--
作者：
Chikazoe, Junichi;Jimura, Koji;Konishi, Seiki
先前的神经心理学、电生理学和神经成像研究表明，右下额叶皮质对反应抑制有贡献。众所周知，额叶下部皮质在处理不常见的刺激时也会被激活，例如刺激驱动的注意力。反应抑制通常使用GO/NO-GO任务来研究，而NO-GO试验通常不经常被用来增强优势反应倾向。因此，在GO/NO-GO任务中，额叶下部的激活是否与反应抑制或对罕见刺激的处理有关，目前还不清楚。在目前的功能磁共振成像研究中，我们不仅使用了经常进行的试验，也使用了不经常进行的试验，这些试验与不进行试验一样不常见。成像结果表明，在反应抑制期间，额叶后下回(PIFG)被激活，如不频繁与不频繁-Go试验所揭示的那样，而额叶下部(IFJ)区域主要在处理不频繁刺激时被激活，如罕见-Go与频繁-Go试验所揭示的那样。这些结果表明，额叶下部皮质内的pIFG和IFJ在空间上是接近的，但在Go/no-Go范式中与不同的认知控制过程有关。
The contribution of the right inferior frontal cortex to response inhibition has been demonstrated by previous studies of neuropsychology, electrophysiology, and neuroimaging. The inferior frontal cortex is also known to be activated during processing of infrequent stimuli such as stimulus-driven attention. Response inhibition has most often been investigated using the go/no-go task, and the no-go trials are usually given infrequently to enhance prepotent response tendency. Thus, it has not been clarified whether the inferior frontal activation during the go/no-go task is associated with response inhibition or processing of infrequent stimuli. In the present functional magnetic resonance imaging study, we employed not only frequent-go trials but also infrequent-go trials that were presented as infrequently as the no-go trials. The imaging results demonstrated that the posterior inferior frontal gyrus (pIFG) was activated during response inhibition as revealed by the no-go vs. infrequent-go trials, whereas the inferior frontal junction (IFJ) region was activated primarily during processing of infrequent stimuli as revealed by the infrequent-go versus frequent-go trials. These results indicate that the pIFG and IFJ within the inferior frontal cortex are spatially close but are associated with different cognitive control processes in the go/no-go paradigm.