Cutting edge: delay and reversal of T cell tolerance by intratumoral injection of antigen-loaded dendritic cells in an autochthonous tumor model.
Cutting edge: delay and reversal of T cell tolerance by intratumoral injection of antigen-loaded dendritic cells in an autochthonous tumor model.
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DOI：
10.4049/jimmunol.1000265
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发表时间：
2010-06-01
期刊：
影响因子：
--
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Higham EM;Shen CH;Wittrup KD;Chen J
The tumor environment exerts a powerful suppressive influence on infiltrating tumor-reactive T cells. It induces tolerance of adoptively transferred effector T cells as they enter tumors and maintains the tolerance of persisting tumor-infiltrating T cells. In an autochthonous prostate cancer model, in which tumor-reactive CD8 T cells are trackable, we demonstrate that both depletion of endogenous dendritic cells (DCs) and intratumoral injection of Ag-loaded mature DCs delayed the tolerization of tumor-infiltrating effector CD8 T cells. Intratumoral injection of Ag-loaded DCs also reactivated tolerized CD8 T cells in the tumor tissue. The observed effects lasted as long as the injected DCs persisted. These findings are consistent with a critical role of DCs in modulating T cell reactivity in the tumor environment. They also suggest new potential strategies to extend the functionality of transferred effector T cells and to restore function to tolerized tumor-infiltrating T cells for cancer immunotherapy.
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影响因子：
32.4
作者：
Jung, S;Unutmaz, D;Lang, RA
通讯作者：
Lang, RA
影响因子：
3.9
作者：
Ehtesham, M;Kabos, P;Yu, JS
通讯作者：
Yu, JS
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作者：
Zou, WP;Machelon, V;Curiel, TJ
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Curiel, TJ
影响因子：
11.5
作者：
Yamanaka, R;Homma, J;Tanaka, R
通讯作者：
Tanaka, R
DOI：
10.1097/cji.0b013e3181a95165
发表时间：
2009-07
期刊：
Journal of immunotherapy (Hagerstown, Md. : 1997)
影响因子：
--
作者：
Teitz-Tennenbaum S;Li Q;Davis MA;Wilder-Romans K;Hoff J;Li M;Chang AE
通讯作者：
Chang AE