Childhood sexual abuse and the risk for recurrent major depression in Chinese women
Childhood sexual abuse and the risk for recurrent major depression in Chinese women
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DOI：
10.1017/s0033291711001462
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发表时间：
2012-02-01
影响因子：
6.9
通讯作者：
Shi, S.
中科院分区：
文献类型：
--
作者：
Cong, E.;Li, Y.;Shi, S.
背景。西方国家的研究多次表明，有童年性虐待史（CSA）的女性患重度抑郁症（MD）的风险增加。这种关系在中国能找到吗？方法。通过自我报告对两组汉族女性的 CSA 三个水平（非生殖器、生殖器和性交）进行评估：1970 例临床确定的复发性 MD 和 2597 例匹配对照。在个人访谈中评估诊断和其他危险因素信息。通过逻辑回归计算优势比（OR），并通过线性或泊松回归计算回归系数。结果。任何形式的 CSA 均与复发性 MD 显着相关 [OR 3.26，95% 置信区间 (CI) 1.95-5.45]。这种关联随着 CSA 严重程度的增加而加强：非生殖器（OR 2.47，95% CI 1.17-5.23）、生殖器（OR 2.77，95% CI 1.32-5.83）和性交（OR 13.35，95% CI 1.83-97.42）。在考虑了父母的抑郁史、童年情感忽视（CEN）、童年身体虐待（CPA）和亲子关系后，任何形式的CSA和MD之间的关联仍然显着。在抑郁女性中，患有 CSA 的女性发病年龄较早，抑郁发作时间较长，并且患广泛性焦虑症（GAD；OR 1.92，95% CI 1.39-2.66）和心境恶劣（OR 2.16，95% CI 1.52-3.09）的风险增加。结论。在中国女性中，CSA 与 MD 密切相关，并且这种关联随着 CSA 严重程度的增加而增加。患有 CSA 的抑郁女性发病年龄较早，抑郁发作时间较长，并且与广泛性焦虑症 (GAD) 和心境恶劣的共病率较高。尽管不能排除报告偏差，但我们的结果与假设一致，即与西方国家一样，CSA 大大增加了中国患 MD 的风险。 2011 年 3 月 2 日收到； 2011 年 7 月 6 日修订； 2011 年 7 月 6 日接受； 2011 年 8 月 11 日首次在线发布
Background. Studies in Western countries have repeatedly shown that women with a history of childhood sexual abuse (CSA) are at increased risk for developing major depression (MD). Would this relationship be found in China?Method. Three levels of CSA (non-genital, genital, and intercourse) were assessed by self-report in two groups of Han Chinese women: 1970 clinically ascertained with recurrent MD and 2597 matched controls. Diagnostic and other risk factor information was assessed at personal interview. Odds ratios (ORs) were calculated by logistic regression and regression coefficients by linear or Poisson regression.Results. Any form of CSA was significantly associated with recurrent MD [OR 3.26, 95% confidence interval (CI) 1.95-5.45]. This association strengthened with increasing CSA severity : non-genital (OR 2.47, 95% CI 1.17-5.23), genital (OR 2.77, 95% CI 1.32-5.83) and intercourse (OR 13.35, 95% CI 1.83-97.42). The association between any form of CSA and MD remained significant after accounting for parental history of depression, childhood emotional neglect (CEN), childhood physical abuse (CPA) and parent-child relationship. Among the depressed women, those with CSA had an earlier age of onset, longer depressive episodes and an increased risk for generalized anxiety disorder (GAD; OR 1.92, 95% CI 1.39-2.66) and dysthymia (OR 2.16, 95% CI 1.52-3.09).Conclusions. In Chinese women CSA is strongly associated with MD and this association increases with greater severity of CSA. Depressed women with CSA have an earlier age of onset, longer depressive episodes and increased co-morbidity with GAD and dysthymia. Although reporting biases cannot be ruled out, our results are consistent with the hypothesis that, as in Western countries, CSA substantially increases the risk for MD in China. Received 2 March 2011; Revised 6 July 2011; Accepted 6 July 2011; First published online 11 August 2011