Cognitive function in normal-weight, overweight, and obese older adults: An analysis of the advanced cognitive training for independent and vital elderly cohort
Cognitive function in normal-weight, overweight, and obese older adults: An analysis of the advanced cognitive training for independent and vital elderly cohort
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DOI：
10.1111/j.1532-5415.2005.00522.x
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发表时间：
2006-01-01
影响因子：
6.3
通讯作者：
Lipsitz, LA
中科院分区：
文献类型：
--
作者：
Kuo, HK;Jones, RN;Lipsitz, LA
目的：评估体重指数 (BMI) 升高如何影响老年人的认知功能。设计：横断面研究。背景：这项横断面研究的数据取自一项多中心随机对照试验，即独立和重要老年人高级认知训练试验。参与者：分析样本包括 2,684 名 65 至 94 岁的正常体重、超重或肥胖受试者。测量：认知能力评估为在多个领域进行：全局认知、记忆、推理和处理速度。使用多元线性回归分析体重状态和认知功能之间的横断面关联。 结果：超重受试者在推理任务（β=0.23，标准误差（SE）=0.11，P=.04）和有用视野（UFOV）测量（β=-39.46，SE=12.95，P=.002）（一项视觉空间处理速度测试）上表现更好，在控制了年龄、性别、种族、受教育年限、干预组、研究地点和心血管危险因素。在多变量模型中，I 级（BMI 30.0-34.9 kg/m(2)）和 II 级（BMI > 35.0 kg/m(2)）肥胖受试者的 UFOV 测量得分（分别为 beta=-38.98、SE=14.77、P=.008；beta=-35.75、SE=17.65 和 P=.04）优于正常体重受试者。 BMI 和个人认知领域之间的关系是非线性的。结论：超重参与者在推理和视觉空间处理速度方面比正常体重参与者具有更好的认知表现。与正常体重相比，肥胖与更好的视觉空间处理速度表现相关。 BMI与认知功能之间的关系应进行前瞻性研究。
OBJECTIVES: To assess how elevated body mass index (BMI) affects cognitive function in elderly people.DESIGN: Cross-sectional study.SETTING: Data for this cross-sectional study were taken from a multicenter randomized controlled trial, the Advanced Cognitive Training for Independent and Vital Elderly trial.PARTICIPANTS: The analytic sample included 2,684 normal-weight, overweight, or obese subjects aged 65 to 94.MEASUREMENTS: Evaluation of cognitive abilities was performed in several domains: global cognition, memory, reasoning, and speed of processing. Cross-sectional association between body weight status and cognitive functions was analyzed using multiple linear regression.RESULTS: Overweight subjects had better performance on a reasoning task (beta=0.23, standard error (SE)=0.11, P=.04) and the Useful Field of View (UFOV) measure (beta=-39.46, SE=12.95, P=.002), a test of visuospatial speed of processing, after controlling for age, sex, race, years of education, intervention group, study site, and cardiovascular risk factors. Subjects with class I (BMI 30.0-34.9 kg/m(2)) and class II (BMI > 35.0 kg/m(2)) obesity had better UFOV measure scores (beta=-38.98, SE=14.77, P=.008; beta=-35.75, SE=17.65, and P=.04, respectively) in the multivariate model than normal-weight subjects. The relationships between BMI and individual cognitive domains were nonlinear.CONCLUSION: Overweight participants had better cognitive performance in terms of reasoning and visuospatial speed of processing than normal-weight participants. Obesity was associated with better performance in visuospatial speed of processing than normal weight. The relationship between BMI and cognitive function should be studied prospectively.