Urine and serum microRNA-1 as novel biomarkers for myocardial injury in open-heart surgeries with cardiopulmonary bypass.
Urine and serum microRNA-1 as novel biomarkers for myocardial injury in open-heart surgeries with cardiopulmonary bypass.
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DOI：
10.1371/journal.pone.0062245
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Zhang C
中科院分区：
文献类型：
--
作者：
Zhou X;Mao A;Wang X;Duan X;Yao Y;Zhang C
microRNA-1（miR-1）是一种心脏特异性/富集的microRNA。我们最近的研究表明，血清和尿液中的miR-1可能是一种新的敏感的急性心肌梗死的生物标志物。体外循环心内直视手术常伴有手术损伤和体外循环相关心脏损伤。然而，miR-1与这些术中和术后心脏损伤的关联尚不清楚。本研究的目的是检验尿液和血清miR-1可能是CPB心脏直视手术中心肌损伤的新生物标志物的假设。在术前、CPB前、CBP后60 min和CBP后24 h测定20例择期二尖瓣手术患者的血清和尿液miR-1水平。血清心肌肌钙蛋白I（cTnI）用作心脏损伤的阳性对照生物标志物。与术前组和CPB前组相比，心内直视手术和CPB后患者血清和尿液中miR-1的水平在所有观察时间点均显著升高。在这些患者中发现了类似的血清cTnI水平模式及其与miR-1水平的强正相关性。结果表明，血清和尿液中的miR-1可能是一种新的敏感的生物标志物，在体外循环心脏直视手术中的心肌损伤。
MicroRNA-1 (miR-1) is a cardio-specific/enriched microRNA. Our recent studies have revealed that serum and urine miR-1 could be a novel sensitive biomarker for acute myocardial infarction. Open-heart surgeries with cardiopulmonary bypass (CPB) are often accompanied with surgery injury and CPB-associated injury on the hearts. However, the association of miR-1 and these intra-operative and post-operative cardiac injures is unknown. The objective of this study was to test the hypothesis that urine and serum miR-1 might be a novel biomarker for myocardial injuries in open-heart surgeries with CPB. Serum and urine miR-1 levels in 20 patients with elective mitral valve surgery were measured at pre-surgery, pre-CPB, 60 min post-CBP, and 24h post-CBP. Serum cardiac troponin-I (cTnI) was used as a positive control biomarker for cardiac injury. Compared with these in pre-operative and pre-CPB groups, the levels of miR-1 in serum and urine from patients after open-heart surgeries and CPB were significant increased at all observed time points. A similar pattern of serum cTnI levels and their strong positive correlation with miR-1 levels were identified in these patients. The results suggest that serum and urine miR-1 may be a novel sensitive biomarker for myocardial injury in open-heart surgeries with CPB.
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DOI：
10.1016/s0006-291x(02)02248-9
发表时间：
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