The respiratory microbiome and innate immunity in asthma.
The respiratory microbiome and innate immunity in asthma.
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DOI：
10.1097/mcp.0000000000000124
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发表时间：
2015-01
影响因子：
3.3
通讯作者：
Huang YJ
中科院分区：
文献类型：
--
作者：
Huang YJ
本研究的目的是综述哮喘下呼吸道微生物群、天然免疫在哮喘中的作用以及了解复杂的微生物群-免疫相互作用在哮喘中的最新研究进展。最近的证据表明，与健康人相比，哮喘患者下呼吸道微生物区系的组成在各种疾病严重程度上都发生了变化。这种改变的呼吸道微生物群的属性与哮喘的临床和炎症特征有关。与生俱来的免疫细胞和粘膜防御系统在哮喘中的重要性日益受到重视，并可能在疾病中受到失调。哮喘的呼吸道微生物群和天然粘膜免疫之间的相互作用是复杂的，是一个具有挑战性的解剖。需要利用多种方法进行多途径的研究，以了解哮喘患者的临床和炎症表型与功能的关系。
The purpose of this study is to summarize recent studies of the lower respiratory microbiome in asthma, the role of innate immunity in asthma and strategies to understand complex microbiome–immune interactions in asthma. Recent evidence indicates that the composition of lower respiratory microbiota in asthmatic individuals, across a spectrum of disease severity, is altered compared with healthy individuals. Attributes of this altered airway microbiome have been linked to clinical and inflammatory features of asthma. The importance of innate immune cells and mucosal defense systems in asthma is increasingly appreciated and may be dysregulated in the disease. Interactions between the respiratory microbiome and innate mucosal immunity in asthma are complex and a challenge to dissect. Multiple avenues of investigation, leveraging a variety of methodologies, will need to be pursued to understand functional relationships to clinical and inflammatory phenotypes seen in asthma.