RELATIONSHIP OF BLOOD-FLOW AND OXYGEN-CONSUMPTION TO ISCHEMIC-INJURY IN THE CANINE SMALL-INTESTINE
RELATIONSHIP OF BLOOD-FLOW AND OXYGEN-CONSUMPTION TO ISCHEMIC-INJURY IN THE CANINE SMALL-INTESTINE
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DOI：
10.1016/0016-5085(85)90583-9
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发表时间：
1985-01-01
期刊：
影响因子：
29.4
通讯作者：
GRANGER, DN
中科院分区：
文献类型：
--
作者：
BULKLEY, GB;KVIETYS, PR;GRANGER, DN
通过测定血中131 - i -白蛋白在犬空肠离体灌注段腔内的清除率，探讨血流量和氧摄取与缺血性肠损伤的关系。血流量减少2小时至不同水平证实了先前证明的摄氧量与血流量的关系，即在血流量超过30 ml/min时，摄氧量与血流无关。100g，低于100g时依赖于流量。高于这个阈值的血流量没有改变对照条件下的白蛋白清除率（0.022 .+-）。0.003 ml/min。100克)。然而，在血流量减少到摄氧量减少50%以上的水平后，可以看到粘膜对白蛋白的通透性增加。这些发现表明，即使在长时间的低灌注状态下，小肠维持氧气消耗的能力可能是提供缺血性损伤保护的重要因素。
The relationship of blood flow and oxygen uptake to ischemic intestinal injury was investigated by measuring the clearance of 131I-albumin from the blood to the lumen of isolated, perfused segments of canine jejunum. Reductions in blood flow for 2 h to various levels confirmed the previously demonstrated relationship of oxygen uptake to blood flow, i.e., oxygen uptake was flow-independent at blood flows above 30 ml/min .cntdot. 100 g, and flow-dependent at levels below this. Blood flows above this threshold did not change the level of albumin clearance seen under control conditions (0.022 .+-. 0.003 ml/min .cntdot. 100 g). However, increases in the mucosal permeability to albumin were seen after blood flow was reduced to levels where oxygen uptake was decreased by more than 50%. These findings indicate that the ability of the small intestine to maintain oxygen consumption during low flow states may be an important factor in providing protection from ischemic injury, even during prolonged periods of hypoperfusion.