Cellular mechanisms of renin release.
Cellular mechanisms of renin release.
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肾素释放的细胞机制。
DOI：
10.1080/07300077.1988.11878910
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Churchill,PC
中科院分区：
文献类型：
--
作者：
Churchill,PC
肾素-血管紧张素系统在盐分和水分平衡以及调节动脉血压方面起着核心作用。这一系统的活性水平主要由肾小球旁颗粒细胞(JG细胞)分泌肾素进入血液的速率决定。从生理上讲，肾素的分泌速率受许多第一信使控制：传入小动脉跨壁压力或其某些功能，如牵张(压力感受器机制)；肾单位致密斑段的溶质运输(致密黄斑机制)；肾神经和肾上腺髓质释放的儿茶酚胺(β-肾上腺素能机制)；许多有机和无机物质的细胞外浓度，包括血管紧张素II、加压素、钾和镁(1-3)。除了这些生理上的第一信使外，许多药理物质也会影响肾素的分泌[3]。细胞生物学公认的原则是，第一信使只影响少数第二信使的细胞内浓度。最近详细综述了细胞内游离离子钙、环AMP和环GMP是肾素分泌的第二信使的证据(4-9)。这些评论被广泛引用，因为篇幅限制排除了引用所有原始文献的可能性。
The renin-angiotensin system plays a central role in salt and water balance and in the regulation of arterial blood pressure. The level of activity of this system is determined primarily by the rate at which the granulated juxtaglomerular cells (JG cells) secrete renin into the blood. Physiologically, renin secretory rate is controlled by a number of first messengers: afferent arteriolar transmural pressure or some function of it, such as stretch (the baroreceptor mechanism); solute transport in the macula densa segment of the nephron (the macula densa mechanism); catecholamines released from the renal nerves and the adrenal medulla (the β-adrenergic mechanism); extracellular concentrations of many organic and inorganic substances including angiotensin II, vasopressin, K, and Mg (1-3). In addition to these physiological first messengers, a number of pharmacological agents affect renin secretion (3).It is an accepted principle of cellular biology that first messengers act by affecting the intracellular concentrations of only a few second messengers. The evidence that intracellular free ionic calcium, cyclic AMP, and cyclic GMP are second messengers in renin secretion has been reviewed in detail recently (4-9). These reviews are cited extensively, since space limitations precluded citing all the original literature.