Development of a control task for clarifying the neural mechanisms underlying tool-use behavior in rats (Rattus norvegicus)
Development of a control task for clarifying the neural mechanisms underlying tool-use behavior in rats (Rattus norvegicus)
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开发控制任务以阐明大鼠（褐家鼠）工具使用行为背后的神经机制
DOI：
10.1016/j.mex.2019.11.022
复制
发表时间：
2019
期刊：
影响因子：
1.9
通讯作者：
Nagano Akane
中科院分区：
文献类型：
--
作者：
Suzuka J;Tsuda M;Wang L;Kohsaka S;Kishida K;Semba S;Sugino H;Aburatani S;Frauenlob M;Kurokawa T;Kojima S;Ueno T;Ohmiya Y;Mano H;Yasuda K;Gong JP;Tanaka S;Nagano Akane
许多关于非人类动物的研究试图探索工具使用行为背后的神经机制。然而，以前的研究表明，工具使用和控制任务之间存在着相当大的非工具使用特定差异。本研究的目的是开发一项控制训练任务，用于研究啮齿动物使用工具背后的神经机制。8只大鼠接受了不包括工具使用特定因素的控制任务，包括拉钩和选择钩子任务的训练，以及包括工具使用特定因素的工具选择测试，与先前对大鼠的研究类似。除一只大鼠外，钩子选择训练的结果表明，先前的研究和本研究的难度水平相似。在本研究的工具选择测试中，在外观和功能之间不存在矛盾的情况下，大鼠不会选择功能性工具而不是非功能性工具，这与本研究所基于的先前研究形成了鲜明对比。这些结果表明，排除工具使用特定因素的训练任务可以适当地用作研究动物以及潜在的人类使用工具背后的神经机制的控制任务。·没有工具使用特定因素的钩子选择训练可以作为控制任务进行。·之前的工具使用培训提高了大鼠在实验测试中的表现。·啮齿动物的控制任务允许研究工具使用的神经机制。
Many studies on non-human animals have attempted to investigate the neural mechanisms underlying tool-use behavior. However, previous studies showed considerable non-tool-use-specific differences between tool-use and control tasks. The purpose of the present study was to develop a control training task for studies that investigate the neural mechanisms behind tool-use in rodents. Eight rats were subjected to control tasks which excluded tool-use-specific factors and consisted of training for hook-pulling and hook-choice tasks, as well as tool-choice tests which included tool-use specific factors and were similar to those in a previous study on rats. With the exception of one rat, the results of the hook-choice training showed that the previous study and the present study had similar difficulty levels. In the tool-choice tests of the present study, rats did not choose the functional tools over the non-functional tools when there was no contradiction between their appearance and functionality, which contrasted with the previous study on which this study was based on. These results suggest that the training task that excludes tool-use-specific factors can be appropriately utilized as a control task for studies investigating the neural mechanisms behind tool-use in animals and, potentially, in humans.•Hook-choice training without tool-use-specific factors can be performed as a control task.•Prior tool-use training improved rats’ performance in experimental tests.•Control task for rodents allows investigation of the neural mechanisms of tool-use.
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