Neutrophil extracellular trap (NET) impact on deep vein thrombosis.
Neutrophil extracellular trap (NET) impact on deep vein thrombosis.
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DOI：
10.1161/atvbaha.111.242859
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发表时间：
2012-08
期刊：
影响因子：
--
通讯作者：
Wagner DD
中科院分区：
文献类型：
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作者：
Fuchs TA;Brill A;Wagner DD
深静脉血栓形成(DVT)是一个主要的健康问题，需要改进预防和治疗。感染、癌症和自身免疫性疾病等炎症性疾病是DVT的危险因素。我们和其他人最近表明，炎症中产生的细胞外DNA纤维，即中性粒细胞外陷阱(Net)，有助于实验性DVT。在DVT动物模型中，Net可促进血栓的形成和凝血，并富含血栓。似乎，除了纤维蛋白和VWF外，Net还代表着第三种血栓支架。在这里，我们回顾了Net如何刺激血栓形成，并讨论了Net与内皮、血小板、红细胞、凝血因子的已知和潜在的相互作用，以及Net如何影响血栓溶解。我们认为抑制净形成或促进净降解的药物可以预防或治疗DVT。
Deep vein thrombosis (DVT) is a major health problem that requires improved prophylaxis and treatment. Inflammatory conditions such as infection, cancer and autoimmune diseases are risk factors for DVT. We and others have recently shown that extracellular DNA fibers produced in inflammation and known as neutrophil extracellular traps (NETs) contribute to experimental DVT. NETs stimulate thrombus formation and coagulation and are abundant in thrombi in animal models of DVT. It appears that, in addition to fibrin and VWF, NETs represent a third thrombus scaffold. Here we review how NETs stimulate thrombosis and discuss known and potential interactions of NETs with endothelium, platelets, red blood cells, coagulation factors and how NETs could influence thrombolysis. We propose that drugs which inhibit NET formation or facilitate NET degradation may prevent or treat DVT.