Microinfusion of the D1 receptor antagonist, SCH23390 into the IL but not the BLA impairs consolidation of extinction of auditory fear conditioning
Microinfusion of the D1 receptor antagonist, SCH23390 into the IL but not the BLA impairs consolidation of extinction of auditory fear conditioning
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DOI：
10.1016/j.nlm.2008.03.003
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发表时间：
2008-07-01
影响因子：
2.7
通讯作者：
Maroun, Mouna
中科院分区：
文献类型：
--
作者：
Hikind, Noam;Maroun, Mouna
在听觉恐惧条件反射中，在没有电击的情况下重复呈现音调会导致获得性恐惧反应的消失。内侧前额叶皮层（mPFC）和基底外侧杏仁核（BLA）都参与了消退。在这里，我们研究了这种参与拮抗D1受体在这两个地区，在大鼠。我们在不同的时间点将D1受体拮抗剂SCH 23390微量注入mPFC（IL）或BLA的边缘下部分。SCH 23390在消退获得之前或在短期消退训练之后微输注到IL中导致消退巩固受损。在获得消退之前，将SCH 23390微输注到BLA中会导致获得消退的损害，而不影响消退巩固。这得到了以下结果的支持，即在短期训练后将SCH 23390微输注到BLA中不会影响巩固。这些结果进一步加强了mPFC在灭绝巩固中的作用，同时突出了D1受体在这一过程中的作用。(C)2008年爱思唯尔公司All rights reserved.
In auditory fear conditioning, repeated presentation of the tone in the absence of the shock leads to extinction of the acquired fear response. Both the medial prefrontal cortex (mPFC) and the basolateral amygdala (BLA) are involved in extinction. Here we examined this involvement by antagonizing D1 receptors in both regions, in the rat. We microinfused the D1 receptor antagonist, SCH23390, into the infra-limbic part of the mPFC (IL) or BLA at different time points. SCH23390 mircoinfused into the IL either before extinction acquisition or following short extinction training resulted in impairment of extinction consolidation. Microinfusion of SCH23390 into the BLA, prior to acquisition of extinction caused impairment in acquisition of extinction without affecting extinction consolidation. This is supported by the results showing that microinfusion of SCH23390 into the BLA following a short-training session did not affect consolidation. These results further strengthen the role of mPFC in consolidation of extinction while highlighting the role of the D1 receptors in this process. (C) 2008 Elsevier Inc. All rights reserved.