A genetic polymorphism in the CYP19A1 gene and the risk of hypertension among midlife women.
A genetic polymorphism in the CYP19A1 gene and the risk of hypertension among midlife women.
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DOI：
10.1016/j.maturitas.2011.10.012
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发表时间：
2012-01
期刊：
影响因子：
4.9
通讯作者：
Flaws JA
中科院分区：
文献类型：
--
作者：
Ziv-Gal A;Gallicchio L;Miller SR;Zacur HA;Flaws JA
旨在测试编码芳香酶的 CYP19A1 基因中的同义单核苷酸多态性（A→G；rs700518）是否与中年女性高血压风险增加相关。在一项横断面研究中，招募了 639 名中年女性。符合条件的女性接受了血压、体重和身高测量，并捐献了血液样本进行激素和基因分析。参与者还完成了详细的研究调查。根据基因型、血压测量值和病史对女性进行分类。使用逻辑回归模型和线性回归模型对数据进行分析。该研究有 80% 的功效检测出平均收缩压（SBP；4.5 mmHg）和舒张压（DBP；3 mmHg）的差异。在未经调整的分析中，所选多态性与高血压和收缩压显着相关。有趣的是，与未患有高血压的女性相比，患有高血压的女性更有可能是 A 等位基因 (AA) 纯合子。此外，与携带其他基因型（AG 或 GG）的女性相比，A 等位基因纯合的女性的平均收缩压显着更高。 DBP 值和基因型之间未经调整的关联具有临界统计显着性 (p=0.07)。然而，在调整潜在的混杂因素（年龄、种族、体重指数（BMI）、吸烟和体力活动）后，基因型与高血压/血压之间的关联减弱，且不具有统计学意义。在我们的中年女性样本中，CYP19A1 中的 rs700518 多态性与高血压无关。其他因素，包括种族和体重指数，似乎也发挥了更大的作用。
To test whether a synonymous single nucleotide polymorphism (A→G; rs700518) in the CYP19A1 gene, which encodes the enzyme aromatase, is associated with an increased risk for hypertension of midlife women. In a cross-sectional study, 639 midlife women were recruited. Eligible women had their blood pressure, weight and height measured, and donated a blood sample for hormone and genetic analyses. The participants also completed a detailed study survey. Women were categorized according to their genotype, blood pressure measurements, and medical history. The data were analyzed using logistic and linear regression models. The study had 80% power to detect differences in mean systolic blood pressure (SBP; 4.5 mmHg) and diastolic blood pressure (DBP; 3 mmHg). The selected polymorphism was significantly associated with hypertension and SBP in unadjusted analyses. Interestingly, women with hypertension were more likely to be homozygous for the A allele (AA) compared to women who were not categorized as having hypertension. Further, the mean SBP was significantly higher for women who were homozygous for the A allele when compared to women carrying the other genotypes (AG or GG). The unadjusted association between DBP values and genotype was of border line statistical significance (p=0.07). However, after adjustment for potential confounders, (age, race, body mass index (BMI), smoking and physical activity) the associations between genotype and hypertension/blood pressure were attenuated and not statistically significant. The rs700518 polymorphism in the CYP19A1 is not associated with hypertension in our sample of midlife women. Other factors, including race and BMI, appear to play a greater role.
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影响因子：
--
作者：
Ferdinand, Keith C;Armani, Annemarie M
通讯作者：
Armani, Annemarie M
影响因子：
4.9
作者：
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通讯作者：
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DOI：
10.1111/j.1524-6175.2004.03563.x
发表时间：
2004-04-01
期刊：
Journal of clinical hypertension (Greenwich, Conn.)
影响因子：
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作者：
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通讯作者：
Jamerson, Kenneth A
DOI：
10.1046/j.1440-1681.2001.03579.x
发表时间：
2001-12-01
影响因子：
2.9
作者：
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通讯作者：
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影响因子：
5.6
作者：
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通讯作者：
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