Tumour microenvironment factors shaping the cancer metabolism landscape.
Tumour microenvironment factors shaping the cancer metabolism landscape.
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DOI：
10.1038/bjc.2016.412
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发表时间：
2017-01
影响因子：
8.8
通讯作者：
Anastasiou D
中科院分区：
文献类型：
--
作者：
Anastasiou D
癌细胞表现出代谢改变，使其与健康组织区分开来，并使其代谢过程容易受到药理学靶向作用的影响。虽然已经出现了典型的癌症代谢的细胞自主特征，但越来越多的人认识到，外在因素也影响肿瘤的代谢特性。这篇综述强调了最近文献中的证据，讨论了肿瘤微环境中的条件如何塑造肿瘤的代谢特征。
Cancer cells exhibit metabolic alterations that distinguish them from healthy tissues and make their metabolic processes susceptible to pharmacological targeting. Although typical cell-autonomous features of cancer metabolism have been emerging, it is increasingly appreciated that extrinsic factors also influence the metabolic properties of tumours. This review highlights evidence from the recent literature to discuss how conditions within the tumour microenvironment shape the metabolic character of tumours.