Assessment of cell-mediated immunity against coxsackievirus B3-induced myocarditis in a primate model (Papio papio).
Assessment of cell-mediated immunity against coxsackievirus B3-induced myocarditis in a primate model (Papio papio).
复制标题
在灵长类动物模型（Papio papio）中评估针对柯萨奇病毒 B3 诱导的心肌炎的细胞介导免疫。
DOI：
10.1128/iai.31.1.470-479.1981
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发表时间：
1981
影响因子：
3.1
通讯作者：
Nealon,TJ
中科院分区：
文献类型：
--
作者：
Paque,RE;Gauntt,CJ;Nealon,TJ
Delayed hypersensitivity and myocarditis were induced in five baboons (Papio papio) after inoculation with myocarditic murine coxsackievirus B3 (CVB3m). By means of the [3H]thymidine incorporation assay and the agarose droplet cell migration inhibition assay, specific cell-mediated immunity was detected in all five animals against viral antigens and/or KCl-extractable soluble antigens extracted from the heart of a CVB3m-inoculated baboon. KCl-extracted antigens from normal baboon heart tissues, as well as KCl-extracted antigens from spleen or liver tissues from a CVB3m-inoculated baboon, failed to stimulate baboon peripheral blood lymphocytes or inhibit the migration of baboon peritoneal exudate cells. The appearance of dissimilar antigen(s) in extracts of heart tissues from CVB3m-inoculated baboons which did not contain infectious CVB3m parallels the appearance of novel KCl-extractable antigen(s) induced by CVB3m in murine heart tissues (Paque et al., J. Immunol. 120:1672-1678). The animal model described represents the first systematic evaluation of cell-mediated immunity in CVB3m-induced myocarditis in primates and suggests that a similar phenomenon may occur in humans.
