Nomenclature of the ARID family of DNA-binding proteins
Nomenclature of the ARID family of DNA-binding proteins
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DOI：
10.1016/j.ygeno.2005.03.013
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发表时间：
2005-08-01
期刊：
影响因子：
4.4
通讯作者：
Moran, E
中科院分区：
文献类型：
--
作者：
Wilsker, D;Probst, L;Moran, E
ARID是一个古老的DNA结合结构域，在高等真核生物的进化过程中是保守的。ARID共有序列跨越约100个氨基酸残基，结构研究将大沟接触位点鉴定为修饰的螺旋-转角-螺旋基序。含有ARID的蛋白质表现出一系列细胞功能，包括参与染色质重塑，以及在细胞生长、分化和发育期间调节基因表达。ARID家族蛋白的一个子集在AT丰富的位点特异性结合DNA;其余的非特异性结合DNA。在昆虫基因组中发现了哺乳动物含ARID蛋白的七个不同亚科中每一个的直系同源物，这表明了这些高等后生动物亚科组织的最小年龄。随着时间的推移，许多这些祖先基因被复制和固定，产生了15个在人类、小鼠和狗基因组中发现的含有ARID的基因。本文介绍了一种命名法，推荐的小鼠基因组命名委员会（MGNC）和接受的人类基因组组织（HUGO）基因命名委员会，这些哺乳动物ARID含有基因，反映了这一进化历史。(c)2005年爱思唯尔公司All rights reserved.
The ARID is an ancient DNA-binding domain that is conserved throughout the evolution of higher eukaryotes. The ARID consensus sequence spans about 100 amino acid residues, and structural studies identify the major groove contact site as a modified helix-turn-helix motif. ARID-containing proteins exhibit a range of cellular functions, including participation in chromatin remodeling, and regulation of gene expression during cell growth, differentiation, and development. A subset of ARID family proteins binds DNA specifically at AT-rich sites; the remainder bind DNA nonspecifically. Orthologs to each of the seven distinct subfamilies of mammalian ARID-containing proteins are found in insect genomes, indicating the minimum age for the organization of these higher metazoan subfamilies. Many of these ancestral genes were duplicated and fixed over time to yield the 15 ARID-containing genes that are found in the human, mouse, and dog genomes. This paper describes a nomenclature, recommended by the Mouse Genomic Nomenclature Committee (MGNC) and accepted by the Human Genome Organization (HUGO) Gene Nomenclature Committee, for these mammalian ARID-containing genes that reflects this evolutionary history. (c) 2005 Elsevier Inc. All rights reserved.