Subgenual cingulate connectivity in children with a history of preschool-depression
Subgenual cingulate connectivity in children with a history of preschool-depression
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DOI：
10.1097/wnr.0b013e32834127eb
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发表时间：
2010-12-29
期刊：
影响因子：
1.7
通讯作者：
Barch, Deanna M.
中科院分区：
文献类型：
--
作者：
Gaffrey, Michael S.;Luby, Joan L.;Barch, Deanna M.
亚属前扣带皮层（sgACC）在抑郁症患者中与大脑其他区域呈现出改变的功能连接。然而，这种现象的发展本质在很大程度上仍未被探究。对36名学龄儿童的sgACC功能连接进行了检测，其中17名有学龄前发病的重性抑郁症（PO - MDD）病史。在健康儿童中，sgACC与认知控制区域的连接增加，而在PO - MDD组中，sgACC与丘脑和顶叶区域的连接增加。还发现失调的情绪行为与sgACC和背内侧前额叶皮层的连接性之间存在显著相关性。这些发现表明，早在学龄期，有PO - MDD病史的儿童就存在非典型的sgACC功能连接，并提示与极早期的抑郁症发作有关。《神经学报道》21：1182 - 1188（C）2010年 沃尔特斯·克卢维尔健康集团 | 利平科特·威廉姆斯和威尔金斯出版社
The subgenual anterior cingulate cortex (sgACC) presents altered functional connections with other regions of the brain in individuals with depression. However, the developmental nature of this phenomenon remains largely unexplored. Functional connections of the sgACC were examined in 36 school age children, 17 with a history of preschool onset major depressive disorder (PO-MDD). The sgACC exhibited increased connections with cognitive control regions in healthy children and increased connections with thalamic and parietal regions in the PO-MDD group. A significant correlation between dysregulated emotional behavior and connectivity of the sgACC and dorsal medial prefrontal cortex was also found. These findings demonstrate that atypical sgACC functional connections are evident as early as school age in children with a history of PO-MDD and suggest an association with a very early episode of depression. NeuroReport 21: 1182-1188 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.