Relationship between radial and central arterial pulse wave and evaluation of central aortic pressure using the radial arterial pulse wave
Relationship between radial and central arterial pulse wave and evaluation of central aortic pressure using the radial arterial pulse wave
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DOI：
10.1291/hypres.30.219
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发表时间：
2007-03-01
影响因子：
5.4
通讯作者：
Yamashina, Akira
中科院分区：
文献类型：
--
作者：
Takazawa, Kenji;Kobayashi, Hideyuki;Yamashina, Akira
由于中央主动脉压的降低有助于预防心血管事件，简单地测量肱动脉压和中央主动脉压可能有助于预防和治疗心血管疾病。在这项研究中，我们同时测量桡动脉脉搏波无创和升主动脉压，在尼可地尔给药前后。在计算主动脉和桡动脉的增强指数（At）的同时，我们比较了中央主动脉压和桡动脉压的变化，这些变化是用肱血压校准的。尼可地尔给药后，主动脉最大收缩压（Delta a-SBP）下降幅度为-14 +/- 15 mmHg，明显大于桡动脉早期收缩压（Delta r-SBP）下降幅度（-9 +/- 12 mmHg）。桡动脉收缩压（δ r-SBP2）降低-15 +/- 14 mmHg，明显大于δ r-SBP，但与δ a-SBP无显著差异。δ a-SBB与δ r- sbp之间存在显著相关性（r=0.81, p < 0.001）， δ a-SBP与δ r- sbp2之间存在显著相关性（r=0.91, p < 0.001）。δ r-SBP2的相关回归线斜率（0.83）比δ r-SBP的相关回归线斜率（0.63）更大，更接近于1，关系接近于1:1。主动脉At （a-Al）与桡动脉At （r- al）有显著相关性（尼可地尔给药前：r=0.91, p < 0.001；给药后：r=0.70, p < 0.001）。这些数据提示，除了常规的肱血压测量外，测量桡动脉脉搏波和观察桡动脉晚期收缩压（r-SBP2）的变化，可以更准确地评估主动脉最大收缩压（a- sbp）的变化。
Since a decrease of central aortic pressure contributes to the prevention of cardiovascular events, simple measurement of not only brachial blood pressure but: also central aortic pressure may be useful in the prevention and treatment of cardiovascular diseases. In this study, we simultaneously measured radial artery pulse waves non-invasively and ascending aortic pressure invasively, before and after the administration of nicorandil. We then compared changes in central aortic pressure and radial arterial blood pressure calibrated with brachial blood pressure in addition to calculating the augmentation index (At) at the aorta and radial artery. After nicorandil administration, the reduction in maximal systolic blood pressure in the aorta (Delta a-SBP) was -14 +/- 15 mmHg, significantly larger than that in early systolic pressure in the radial artery (Delta r-SBP) (-9 +/- 12 mmHg). The reduction in late systolic blood pressure in the radial artery (Delta r-SBP2) was -15 +/- 14 mmHg, significantly larger than Delta r-SBP, but not significantly different from Delta a-SBP. There were significant relationships between Delta a-SBB and Delta r-SBP (r=0.81, p < 0.001), and between Delta a-SBP and Delta r-SBP2 (r=0.91, p < 0.001). The slope of the correlation regression line with Delta r-SBP2 (0.83) was larger and closer to 1 than that with Delta r-SBP (0.63), showing that the relationship was close to 1:1. Significant correlations were obtained between aortic At (a-Al) and radial At (r-Al) (before nicorandil administration: r=0.91, p < 0.001; after administration: r=0.70, p < 0.001). These data suggest that the measurement of radial artery pulse wave and observation of changes in the late systolic blood pressure in the radial artery (r-SBP2) in addition to the ordinary measurement of brachial blood pressure may enable a more accurate evaluation of changes in maximal systolic blood pressure in the aorta (a-SBP).