MOTHER AS SHIELD - DIFFERENTIAL-EFFECTS OF CONTACT AND NURSING ON PAIN RESPONSIVITY IN INFANT RATS - EVIDENCE FOR NONOPIOID MEDIATION
MOTHER AS SHIELD - DIFFERENTIAL-EFFECTS OF CONTACT AND NURSING ON PAIN RESPONSIVITY IN INFANT RATS - EVIDENCE FOR NONOPIOID MEDIATION
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DOI：
10.1037/0735-7044.109.2.342
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发表时间：
1995-04-01
影响因子：
1.9
通讯作者：
SORRENTINO, J
中科院分区：
文献类型：
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作者：
BLASS, EM;SHIDE, DJ;SORRENTINO, J
为了确定大鼠母亲如何保护其幼崽免受疼痛，我们对 10 天大的大鼠的耳朵或肩膀进行局部加热（34-51 摄氏度），这些大鼠被隔离，它们之间或与母亲接触，无营养地哺乳，或处于通常由泌乳引起的过度伸展位置。相对于离体大鼠：接触使耳朵受热（43 或 45 摄氏度）的撤退潜伏期加倍。哺乳期的热逸出潜伏期增加了四倍。过度伸展期间。大鼠基本上无法逃脱高达 48 摄氏度的热刺激。母体接触（尤其是哺乳）提供的保护不是由 mu 或 kappa 阿片受体介导的：全身注射纳曲酮或降比纳托菲明都不会降低热逃逸潜伏期。吗啡（0.125 和 0.250 毫克/千克）会增加接触的影响，但也会增加哺乳的影响，产生超过 2 分钟的热逃逸潜伏期。
To determine how rat mothers protect their pups against pain, we applied focal heat (34-51 degrees C) to the ear or shoulder of 10-day-old rats that were isolated, in contact among themselves or with their mother, suckling nonnutritively, or in the hyperextension position normally caused by milk letdown. Relative to isolated rats: contact doubled withdrawal latencies from heat (43 or 45 degrees C) applied to the ear. Suckling quadrupled heat-escape latencies. During hyperextension. rats essentially did not escape from thermal stimulation of up to 48 degrees C. Protection provided by maternal contact, especially suckling, was not mediated by either mu or kappa opioid receptors: Neither systemic injections of naltrexone nor norbinaltorphimine reduced heat-escape latencies. Morphine (0.125 and 0.250 mg/kg) added to the effects of contact but multiplied the effects of suckling to produce heat-escape latencies that were upward of 2 min.