Anti-oxidant properties of high-density lipoprotein and atherosclerosis
Anti-oxidant properties of high-density lipoprotein and atherosclerosis
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DOI：
10.1111/j.1440-1681.2010.05380.x
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发表时间：
2010-07-01
影响因子：
2.9
通讯作者：
Podrez, Eugene A.
中科院分区：
文献类型：
--
作者：
Podrez, Eugene A.
P>1。高密度脂蛋白（HDL）是血液中胆固醇的主要载体之一。它引起特别的关注，因为与其他脂蛋白相比，HDL的许多生理功能以有利的方式影响心血管系统，除非HDL被病理改变。2． HDL 最著名的功能是促进细胞胆固醇从外周细胞流出并将胆固醇输送至肝脏排泄的能力，从而在胆固醇逆转运中发挥关键作用。最近引起关注的HDL功能包括抗炎和抗氧化活性。 HDL 的高抗氧化和抗炎活性与预防心血管疾病有关。3．动脉粥样硬化活性以及 HDL 的功能缺陷最终取决于 HDL 的蛋白质和脂质组成。相反，这些活性在许多与炎症相关的病理状态下会受到损害。4．本综述的重点是 HDL 及其各个成分与动脉粥样硬化保护相关的抗氧化和抗炎功能。
P>1. High-density lipoprotein (HDL) is one of the major carriers of cholesterol in the blood. It attracts particular attention because, in contrast with other lipoproteins, many physiological functions of HDL influence the cardiovascular system in favourable ways unless HDL is modified pathologically.2. The best known function of HDL is the capacity to promote cellular cholesterol efflux from peripheral cells and deliver cholesterol to the liver for excretion, thereby playing a key role in reverse cholesterol transport. The functions of HDL that have recently attracted attention include anti-inflammatory and anti-oxidant activities. High anti-oxidant and anti-inflammatory activities of HDL are associated with protection from cardiovascular disease.3. Atheroprotective activities, as well as a functional deficiency of HDL, ultimately depend on the protein and lipid composition of HDL. Conversely, these activities are compromised in many pathological states associated with inflammation.4. The focus of the present review is on the anti-oxidant and anti-inflammatory functions of HDL and its individual components in relation to protection from atherosclerosis.