Thrombin-induced platelet microbicidal protein susceptibility phenotype influences the outcome of oxacillin prophylaxis and therapy of experimental Staphylococcus aureus endocarditis.
Thrombin-induced platelet microbicidal protein susceptibility phenotype influences the outcome of oxacillin prophylaxis and therapy of experimental Staphylococcus aureus endocarditis.
复制标题
凝血酶诱导的血小板杀菌蛋白敏感性表型影响苯唑西林预防和治疗实验性金黄色葡萄球菌心内膜炎的结果。
DOI：
10.1128/aac.44.11.3206-3209.2000
复制
发表时间：
2000
影响因子：
4.9
通讯作者：
Yeaman,MR
中科院分区：
文献类型：
--
作者：
Dhawan,VK;Bayer,AS;Yeaman,MR
我们先前的研究表明，金黄色葡萄球菌对凝血酶诱导的血小板微杀菌蛋白1(TPMP-1)的体外敏感性影响万古霉素治疗实验性感染性心内膜炎的疗效。在同一模型中，苯唑西林(一种比万古霉素更快速的葡萄球菌杀灭剂)处理增强了对TPMP-1敏感和耐药细胞从植物中的清除。对TPMP-1敏感的细胞清除程度较大。
We previously showed that in vitro susceptibility profiles ofStaphylococcus aureusto thrombin-induced platelet microbicidal protein 1 (tPMP-1) impacted the outcome of vancomycin treatment in experimental infective endocarditis. In this same model, treatment with oxacillin (a more rapid staphylocidal agent than vancomycin) enhanced the clearance of both tPMP-1-susceptible and -resistant cells from vegetations. The extent of clearance was greater for tPMP-1-susceptible cells.