Tissue factor activities of streptozotocin induced diabetic rat tissues and the effect of peanut consumption
Tissue factor activities of streptozotocin induced diabetic rat tissues and the effect of peanut consumption
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DOI：
10.1002/dmrr.757
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发表时间：
2007-11-01
影响因子：
8
通讯作者：
Yarat, Aysen
中科院分区：
文献类型：
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作者：
Emekli-Alturfan, Ebru;Kasikci, Emel;Yarat, Aysen
背景组织因子(Tf)被认为是正常止血和血栓形成的主要调节因子。提示循环TF活性与糖尿病的发生有关。各种组织和体液都有转铁蛋白活性。本研究旨在研究链脲佐菌素(STZ)诱导的糖尿病大鼠组织中转铁蛋白的活性。据报道，食用花生与降低患2型糖尿病的风险有关。方法24只Wistar大鼠随机分为正常对照组、STZ糖尿病组和糖尿病+花生干预组，每组8只。结果糖尿病组肝、肾、脾、肝、肾、脾、心、肾、肺、胰腺、主动脉组织的组织因子活性较对照组升高(P<0.01)，脑组织组织因子活性较对照组降低(P<0.01)。糖尿病组大鼠摄入花生后，脾、主动脉组织转铁蛋白活性降低(p<；0.01；p<；0.05)。结论糖尿病大鼠组织中TF活性升高，可能是糖尿病并发动脉粥样硬化性血栓形成风险增加的原因之一，而脑组织中TF活性降低可能是由于不同的止血机制保护这一重要器官免受糖尿病的影响。给予糖尿病大鼠组织的花生组织中TF活性降低，可能会保护这些组织免受血栓形成的风险。版权所有(C)2007 John Wiley&Sons，Ltd.
Background Tissue factor (TF) is considered to be a major regulator of normal haemostasis and thrombosis. Circulating TF activity is suggested to be associated with diabetes mellitus. Various tissues and body fluids have TF activity. The aim of the present study was to investigate the TF activity of streptozotocin (STZ) induced diabetic rat tissues. Peanut consumption is reported to be associated with decreased risk of type 2 diabetes. Therefore, the effect of peanut consumption on the TF activity of STZ induced diabetic rat tissues, and haemostatic parameters such as protrombin time (PT), activated partial thromboplastin time (APTT) and fibrinogen levels were determined.Methods Twenty-four Wistar rats were divided into 3 groups of 8 rats each as control, STZ-induced diabetic and diabetic + peanut group. Twelve weeks later, TF activity of liver, kidney, spleen, heart, kidney, lung, pancreas and aorta and haemostatic parameters were determined.Results In the diabetic group, TF activities of liver, kidney and spleen increased (p < 0.01) whereas the TF activity of brain decreased (p < 0.01) compared to the control group. Peanut consumption in the diabetic group decreased the TF activity of spleen and aorta (p < 0.01; p < 0.05). Haemostatic parameters did not change significantly in the groups.Conclusion Elevated TF activity in diabetic rat tissues, may contribute to the increased risk of atherothrombotic disease that accompanies the diabetic complications whereas the decreased brain TF activity may be due to a different haemostatic mechanism to protect this vital organ from the diabetic status. The decreased TF activity of peanut given diabetic rat tissues might protect these tissues from the risk of thrombosis. Copyright (c) 2007 John Wiley & Sons, Ltd.