TRIAZOLAM IN PATIENTS WITH OBSTRUCTIVE SLEEP-APNEA
TRIAZOLAM IN PATIENTS WITH OBSTRUCTIVE SLEEP-APNEA
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DOI：
10.1164/ajrccm.151.2.7842205
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发表时间：
1995-02-01
影响因子：
24.7
通讯作者：
LIGHT, RW
中科院分区：
文献类型：
--
作者：
BERRY, RB;KOUCHI, K;LIGHT, RW
本研究旨在评估三唑仑（0.25 mg）对重度阻塞性睡眠呼吸暂停（OSA）患者睡眠期间呼吸暂停持续时间和气道阻塞的觉醒反应的影响。12名男性受试者，平均（+/- SD）年龄为46.6 ± 14.1岁，体重为260.8 ± 55.9磅，在两个晚上进行研究，中间间隔一个非研究夜晚。以随机双盲交叉的方式，在睡前0.5小时服用三唑仑（0.25 mg）或安慰剂。在非快速眼动（NREM）睡眠中，三唑仑夜晚的平均（+/- SEM）呼吸暂停/低通气持续时间略有增加（26.8 +/- 1.7 vs 23.8 +/- 1.2 s，p < 0.02），动脉血氧饱和度的平均最低值较低（80.1 +/- 1.9 vs 84.2 +/-1.4%，p < 0.001）。在非快速眼动睡眠中，三唑仑治疗的患者在呼吸暂停终止前的食管压力偏移较高（53.3 +/- 5.4 vs 44.5 +/- 4.8 cm H2O，p < 0.001）。然而，三唑仑并未降低阻塞性事件期间吸气努力（食管压力偏转）的增加率。我们得出结论，三唑仑增加觉醒阈值气道阻塞，但这只会导致适度延长事件的持续时间和增加去饱和在一组大的睡眠呼吸暂停患者的剂量为0.25毫克。
The purpose of this study was to assess the effect of triazolam (0.25 mg) on apnea duration and the arousal response to airway occlusion during sleep in patients with severe obstructive sleep apnea (OSA). Twelve male subjects with a mean (+/- SD) age of 46.6 +/- 14.1 yr and body weight of 260.8 +/- 55.9 Ib were studied on two nights separated by a nonstudy night. They ingested triazolam (0.25 mg) or placebo 0.5 h before bedtime in a randomized double-blind crossover manner. In non-rapid-eye-movement (NREM) sleep, the mean (+/- SEM) duration of apnea/hypopnea was slightly increased (26.8 +/- 1.7 versus 23.8 +/- 1.2 s, p < 0.02) and the mean nadir in arterial oxygen saturation lower (80.1 +/- 1.9 versus 84.2 +/- 1.4%, p < 0.001) on triazolam nights. In NREM sleep, the deflections in esophageal pressure prior to apnea termination were higher on triazolam nights (53.3 +/- 5.4 versus 44.5 +/- 4.8 cm H2O, p < 0.001). However, the rate of increase in inspiratory effort (esophageal pressure deflections) during obstructive events was not decreased by triazolam. We conclude that triazolam increases the arousal threshold to airway occlusion, but that this results in only modest prolongation of event duration and increased desaturation at a dose of 0.25 mg in a group of large sleep apnea patients.