Effectiveness of Rosmarinus officinalis essential oil as antihypotensive agent in primary hypotensive patients and its influence on health-related quality of life
Effectiveness of Rosmarinus officinalis essential oil as antihypotensive agent in primary hypotensive patients and its influence on health-related quality of life
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DOI：
10.1016/j.jep.2013.11.006
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发表时间：
2014-01-10
影响因子：
5.4
通讯作者：
Frutos, G.
中科院分区：
文献类型：
--
作者：
Fernandez, L. F.;Palomino, O. M.;Frutos, G.
民族药理学相关性：研究迷迭香精油对原发性低血压的作用及其对患者健康相关生活质量(HRQOL)生理和心理方面的影响。方法：选择2007年3月至2008年9月在西班牙一家药店进行为期72周的前瞻性研究的32名确诊低血压患者。根据美国高血压学会的国际标准，通过控制收缩压和舒张压水平(分别为SBP和DBP)进行临床评估。在整个研究过程中，HRQOL数据被记录在SF-36健康调查(R)问卷中。以统计学方法评价迷迭香精油的降压效果，并评价两个定量变量(SBP和DBP)与SF-36健康状况调查表的身心总分(PSC和MSC)之间的关系。结果：SBP和DBP的血压变量均反映了迷迭香精油在整个治疗过程中维持的临床显著降压作用。经问卷验证(Cronbach‘sα系数>；0.82)，PSC、MSC治疗前后差异有统计学意义，提示这些参数的改善与血压的变化有直接关系。结论：服用迷迭香精油后，血压明显升高。这项前瞻性临床试验的结果证明了统计学方法的有效性，为解释迷迭香精油的降压作用及其与改善患者生活质量的关系提供了新的方法。(C)2013爱思唯尔爱尔兰有限公司。保留所有权利。
Ethnopharmacological relevance: To study Rosmarinus officinalis (Rosemary) essential oil effect on primary hypotension and its influence on both physical and psychological aspects responsible for health-related quality of life (HRQOL) of patients.Methodology: Thirty-two patients with diagnosed hypotension were recruited between March 2007 and September 2008 for a prospective study for 72 weeks in a Spanish pharmacy. Clinical evaluation was carried out through the control of systolic and diastolic blood pressure levels (SBP and DBP, respectively) according to the International Standards from the American Society of Hypertension. HRQOL data were recorded within the SF-36 Health Survey (R) questionnaire throughout the study. Statistical methods were used as the essential tools to evaluate the effectiveness of Rosemary essential oil and to assess the relationship between the two quantitative variables (SBP and DBP) and scores from physical and mental summary components (PSC and MSC) obtained from the SF-36 Health Survey.Results: Both blood pressure variables of SBP and DBP reflect the clinically significant antihypotensive effect of Rosemary essential oil that was maintained throughout the treatment period. After validation of the use of the questionnaire (Cronbach's alpha coefficient > 0.82), statistically significant differences have been found between pre-treatment and post-treatment values of PSC and MSC, which indicate an improvement in these parameters that is directly related to the variation in blood pressure values.Conclusions: The increase achieved in blood pressure values after administration of Rosemary essential oil is clinically significant. The results obtained from this prospective clinical trial prove the effectiveness of statistical methodology as a new approach to explain the antihypotensive effect of rosemary essential oil and its relationship with the improvement in patients' quality of life. (C) 2013 Elsevier Ireland Ltd. All rights reserved.