A follow-up and family study of schizophrenia.
A follow-up and family study of schizophrenia.
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精神分裂症的随访和家庭研究。
DOI：
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发表时间：
1983
影响因子：
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通讯作者：
P. Clayton
中科院分区：
文献类型：
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作者：
S. Guze;C. Robert Cloninger;R. Martin;P. Clayton
位于圣路易斯的华盛顿大学精神病学诊所（Washington University Psychiatry Clinic）对该诊所500名病人的横截面进行了系统的临床评估。接下来是对索引对象的“盲”随访和对一级亲属的盲研究。本报告涉及精神分裂症的诊断在指数，在随访中，并在一级亲属。结果表明，用于诊断精神分裂症的标准选择了多年来表现出高度诊断一致性的患者，尽管并非所有符合这些标准的患者在随访后最初都被诊断为精神分裂症。最重要的是，诊断标准选择了与精神分裂症风险的强烈家族性增加（近五倍）相关的病例。后续研究结果还表明，费格纳阳性的精神分裂症患者经常会出现抑郁症，但这种抑郁症的存在并不影响精神分裂症或原发性情感障碍的家族发病率。
The Washington University Psychiatry Clinic, St Louis, study began with the systematic clinical evaluation of a cross section of 500 of the clinic's patients. This was followed by a "blind" follow-up of the index subjects and a blind study of first-degree relatives. This report deals with the diagnosis of schizophrenia at index, at follow-up, and among the first-degree relatives. The results indicate that the criteria used for the diagnosis of schizophrenia select patients who show a high degree of diagnostic consistency over many years, although not all patients who meet these criteria after follow-up receive the diagnosis of schizophrenia initially. Most important, the diagnostic criteria select cases associated with a strong familial increase in the risk of schizophrenia (nearly fivefold). The follow-up results indicate also that Feighner-positive schizophrenics often experience intercurrent depressions, but that the presence of such depressions does not affect the familial incidence of either schizophrenia or primary affective disorders.