Essential oil based polymeric patch development and evaluating its repellent activity against mosquitoes
Essential oil based polymeric patch development and evaluating its repellent activity against mosquitoes
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DOI：
10.1016/j.actatropica.2015.03.027
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发表时间：
2015-07-01
期刊：
影响因子：
2.7
通讯作者：
Veer, Vijay
中科院分区：
文献类型：
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作者：
Chattopadhyay, Pronobesh;Dhiman, Sunil;Veer, Vijay
基于精油的驱虫剂对环境友好，并提供可靠的个人保护，防止蚊子和其他吸血昆虫的叮咬。在本研究中，将三种精油的优化混合物嵌入乙基纤维素（EC）和聚乙烯吡咯烷酮（PVP K-30）聚合物中，开发基于精油的贴片型驱蚊剂配方。所开发的配方具有各种物理化学性质、油释放效率和精油-聚合物相互作用的特征。评价制剂对Ae的驱避活性。 (S) 白纹伊蚊，并在实验室中与市售合成杀虫剂驱蚊膏 Odomos (R) 进行比较。开发出来的贴剂是 100% 平坦的，并且油成分和赋形剂之间没有相互作用。贴片光滑、均匀，并在实验室条件下提供与 Odomos (R) 相当的出色驱蚊活性。形态和物理化学表征表明该配方稳定且适合聚合物组合。该贴剂制剂在实验 Wistar 大鼠中未显示任何吸入毒性。目前开发和评估的驱虫贴片可以为现有的合成驱虫剂配方提供合适的、环保的、可接受的和安全的替代品，以实现对蚊子的防护。 (C) 2015 Elsevier B.V. 保留所有权利。
Essential oil based insect repellents are environment friendly and provide dependable personal protection against the bites of mosquitoes and other blood-sucking insects. In the present study, optimized mixture of three essential oils was embedded into the ethylcellulose (EC) and polyvinylpyrrolidone (PVP K-30) polymers to develop essential oils based patch type mosquito repellent formulation. The developed formulation was characterized for various physico-chemical properties, oil release efficiency and essential oil-polymer interaction. Repellent activity of the formulation was evaluated against Ae. (S) albopictus mosquitoes and compared with commercially available synthetic insecticide based mosquito repellent cream Odomos (R) in the laboratory. The developed patches were 100% flat and there was no interaction between oil components and the excipients. Patches were smooth, homogenous and provided excellent mosquito repellent activity comparable to Odomos (R) under laboratory condition. Morphological and physico-chemical characterization indicated that the formulation was stable and suitable with the polymeric combination. The patch formulation did not show any inhalation toxicity in experimental Wistar rat. The repellent patches developed and evaluated currently, may provide a suitable, eco-friendly, acceptable and safe alternative to the existing synthetic repellent formulations for achieving protection against mosquitoes. (C) 2015 Elsevier B.V. All rights reserved.