Combination Treatment of C16 Peptide and Angiopoietin-1 Alleviates Neuromyelitis Optica in an Experimental Model.
Combination Treatment of C16 Peptide and Angiopoietin-1 Alleviates Neuromyelitis Optica in an Experimental Model.
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DOI：
10.1155/2018/4187347
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发表时间：
2018
影响因子：
4.6
通讯作者：
Han S
中科院分区：
文献类型：
--
作者：
Zhang Y;Tian K;Jiang H;Wang B;Han S
视神经肌萎缩症（NMO）是一种自身免疫性炎性脱髓鞘疾病，主要影响脊髓和视神经，导致失明和瘫痪，在一些人。此外，NMO可引起继发性补体依赖性细胞毒性（CDC），导致少突胶质细胞和神经元损伤。在这项研究中，啮齿动物NMO模型，显示典型的NMO发病机制，诱导与NMO-IgG从患者血清和人补体。然后，我们测试了C16（αvβ3整合素结合肽）和血管生成素-1（Ang 1）（内皮生长因子家族成员）的组合是否可以减轻模型中的NMO。我们的研究结果表明，这种联合治疗显着降低疾病的严重程度，炎性细胞浸润，继发性脱髓鞘和轴突损失，从而减少神经死亡。总之，我们的研究表明了一种可能的治疗方法，可以通过改善炎症环境来缓解NMO动物模型中的进行性失明和瘫痪。
Neuromyelitis optica (NMO) is an autoimmune inflammatory demyelinating disease that mainly affects the spinal cord and optic nerve, causing blindness and paralysis in some individuals. Moreover, NMO may cause secondary complement-dependent cytotoxicity (CDC), leading to oligodendrocyte and neuronal damage. In this study, a rodent NMO model, showing typical NMO pathogenesis, was induced with NMO-IgG from patient serum and human complement. We then tested whether the combination of C16, an αvβ3 integrin-binding peptide, and angiopoietin-1 (Ang1), a member of the endothelial growth factor family, could alleviate NMO in the model. Our results demonstrated that this combination therapy significantly decreased disease severity, inflammatory cell infiltration, secondary demyelination, and axonal loss, thus reducing neural death. In conclusion, our study suggests a possible treatment that can relieve progressive blindness and paralysis in an animal model of NMO through improvement of the inflammatory milieu.
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影响因子：
4.6
作者：
Han S;Zhang F;Hu Z;Sun Y;Yang J;Davies H;Yew DT;Fang M
通讯作者：
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影响因子：
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通讯作者：
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影响因子：
5.6
作者：
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通讯作者：
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