Sex hormone modulation of flow velocity in the parametrial artery of the pregnant rat.
Sex hormone modulation of flow velocity in the parametrial artery of the pregnant rat.
复制标题
性激素对怀孕大鼠宫旁动脉流速的调节。
DOI：
10.1152/ajpregu.1995.268.3.r614
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
W. Utian
中科院分区：
文献类型：
--
作者：
G. Gorodeski;L. Sheean;W. Utian
本研究的目的是将大鼠子宫段成熟的不同远端/近端状态与子宫旁动脉的血流动力学相关联。流速通过亚甲基蓝光度分析测定。在非妊娠动物中，宫旁动脉远端（VD->P）和近端（VP->D）的流速相似，但在妊娠晚期，VD->P高于VP->D。这种差异与子宫旁动脉远端部分的宽度增加有关。此外，与非妊娠动物相比，妊娠晚期动物与D-->P和P-->D流碰撞的宫旁动脉近端的距离减少。雌二醇和RU-486治疗可逆转妊娠相关的血流动力学变化。子宫旁动脉中与妊娠相关的血流速度变化对大鼠胎儿在子宫内的存活至关重要，并且可能是体内促进子宫角远侧段与近侧段相比成熟的机制。
The objective of the study was to correlate the disparate distal/proximal state of maturation of uterine segments in the rat with the hemodynamics of the parametrial uterine artery. Flow velocity was determined by the methylene blue photometric analysis. In nonpregnant animals, the velocity in the distal (VD-->P) and proximal (VP-->D) portions of the parametrial artery were similar, but in late pregnancy, VD-->P was higher than VP-->D. The difference was associated with an increased width of the distal part of the parametrial artery. In addition, the distance from the proximal end of the parametrial artery where the D-->P and P-->D streams collided decreased in animals in late pregnancy, compared with nonpregnant animals. Treatment with estradiol and RU-486 reversed the pregnancy-related hemodynamic changes. The pregnancy-related shift in flow velocity in the parametrial artery is crucial to rat fetal survival in utero and may be a mechanism in vivo for promoting maturation of distal, compared with proximal, segments of the uterine horn.