Regulation of hematopoiesis by activators and inhibitors of Wnt signaling from the niche
Regulation of hematopoiesis by activators and inhibitors of Wnt signaling from the niche
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DOI：
10.1111/nyas.12384
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发表时间：
2014-01-01
期刊：
影响因子：
--
通讯作者：
Istvanffy, Rouzanna
中科院分区：
文献类型：
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作者：
Schreck, Christina;Bock, Franziska;Istvanffy, Rouzanna
造血干细胞（HSC）是一种罕见的成体干细胞群体，具有在成年期以分层方式再生整个成熟血液系统的能力。成体HSC位于骨髓龛中。在正常和恶性造血中，不同的小生境细胞类型和分子调节HSC休眠和激活的平衡以及HSC的行为。在这里，我们描述了造血干细胞及其生态位的相互作用，特别是Wnt信号通路的参与。虽然流行的观点是HSC的恶性转化是白血病的主要原因，但越来越多的证据表明，转化的造血细胞（可能过度表达Wnt信号传导或基因表达中的内在基质缺陷）对生态位调节的破坏至少是白血病发生中的一个协同因素。因此，洞察到正常和改变功能的生态位组件将有助于获得更好地了解正常和恶性造血以及环境因素如何影响这些过程。
Hematopoietic stem cells (HSCs) are a rare population of somatic stem cells that have the ability to regenerate the entire mature blood system in a hierarchical way for the duration of an adult life. Adult HSCs reside in the bone marrow niche. Different niche cell types and molecules regulate the balance of HSC dormancy and activation as well as HSC behavior in both normal and malignant hematopoiesis. Here, we describe the interplay of HSCs and their niche, in particular the involvement of the Wnt signaling pathway. Although the prevailing notion has been that malignant transformation of HSCs is the main cause of leukemia, evidence is mounting that disruption of niche regulation by transformed hematopoietic cells, which may overexpress Wnt signaling or intrinsic stromal defects in gene expression, is at least a collaborative factor in leukemogenesis. Thus, insights into the normal and altered functions of niche components will help to obtain a better understanding of normal and malignant hematopoiesis and how environmental factors affect these processes.