Monoamine synaptic structure and localization in the central nervous system.
Monoamine synaptic structure and localization in the central nervous system.
复制标题
单胺突触结构和中枢神经系统定位。
DOI：
10.1002/jemt.1060150104
复制
发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Elde,RP
中科院分区：
文献类型：
--
作者：
Maley,BE;Engle,MG;Humphreys,S;Vascik,DA;Howes,KA;Newton,BW;Elde,RP
单胺多巴胺、去甲肾上腺素、肾上腺素和血清素以及二胺组胺在中枢神经系统的突触末梢和非突触静脉曲张内广泛分布。在中枢神经系统的某些区域，单胺包含在静脉曲张中，而静脉曲张没有与之相关的突触特化，这表明某些单胺可能具有神经调节作用。大多数单胺标记结构是突触末端，其特征是末端内存在小而透明的囊泡（40-60 nm）和大的颗粒状囊泡（70-120 nm）。第三种囊泡——小颗粒状囊泡——仅在组织化学染色后可见，可能相当于放射自显影或免疫组织化学标记后出现的小而透明的囊泡。大多数含有单胺的末端接触树突和树突棘，以及较少见的神经元胞体和其他轴突。不对称和对称膜特化均与单胺能末端相关。然而，不对称接触是最常见的类型。这些超微结构结果表明，含有单胺的末端和静脉通常具有许多共同的形态特征，但仍然具有不同的功能。
The monoamines dopamine, noradrenaline, adrenaline, and serotonin as well as the diamine histamine have a widespread distribution in the central nervous system within synaptic terminals and nonsynaptic varicosities. In certain regions of the central nervous system the monoamines are contained in varicosities that have no synaptic specialization associated with them, suggesting a possible neuromodulatory role for some of the monoamines. The majority of monoamine labelled structures are synaptic terminals which are characterized by the presence of small, clear vesicles (40–60 nm) and large, granular vesicles (70–120 nm) within the terminal. A third population of vesicles—small, granular vesicles—which are visible only after histochemical staining, are probably the equivalent of the small, clear vesicles present after either autoradiographic or immunohistochemical labelling. Most monoamine containing terminals contact dendrites and dendritic spines and, less frequently, neuronal somata and other axons. Both asymmetrical and symmetrical membrane specializations are associated with monoaminergic terminals; however, asymmetrical contacts are the most frequent type found. These ultrastructural results indicate that monoamine containing terminals and varicosities in general share many common morphological features, but still have diverse functions.