GABAA-current rundown of temporal lobe epilepsy is associated with repetitive activation of GABAA "phasic" receptors
GABAA-current rundown of temporal lobe epilepsy is associated with repetitive activation of GABAA "phasic" receptors
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DOI：
10.1073/pnas.0710522105
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发表时间：
2007-12-26
影响因子：
11.1
通讯作者：
Eusebi, Fabrizio
中科院分区：
文献类型：
--
作者：
Palma, Eleonora;Roseti, Cristina;Eusebi, Fabrizio
A study was made of the "rundown" of GABA(A) receptors, microtransplanted to Xenopus oocytes from surgically resected brain tissues of patients afflicted with drug-resistant human mesial temporal lobe epilepsy (mTLE). Cell membranes, isolated from mTLE neocortex specimens, were injected into frog oocytes that rapidly incorporated functional GABAA receptors. Upon repetitive activation with GABA (1 mM), "epileptic" GABAA receptors exhibited a GABA(A)-current I-GABA rundown that was significantly enhanced by Zn2+ (
