Simultaneous determination of the conformation and relative configuration of archazolide A by using nuclear Overhauser effects, J couplings, and residual dipolar couplings
Simultaneous determination of the conformation and relative configuration of archazolide A by using nuclear Overhauser effects, J couplings, and residual dipolar couplings
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DOI：
10.1002/anie.200800225
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发表时间：
2008-01-01
影响因子：
16.6
通讯作者：
Carlomagno, Teresa
中科院分区：
文献类型：
--
作者：
Fares, Christophe;Hassfeld, Jorma;Carlomagno, Teresa
组合与征服：复杂的聚酮化合物大环内酯古唑内酯 A（参见结构；红色 O、蓝色 N、黄色 S）中远程立体中心的构型分配是通过纯粹基于 NMR 的方法完成的，该方法依赖于核 Overhauser 效应、J 耦合和残余偶极耦合 (RDC) 的组合。
Combine and conquer: Configurational assignment of remote stereogenic centers in the complex polyketide macrolide archazolide A (see structure; red O, blue N, yellow S) was accomplished by a purely NMR-based approach relying on a combination of nuclear Overhauser effects, J couplings, and residual dipolar couplings (RDCs).