Computational and experimental approaches for investigating nanoparticle-based drug delivery systems
Computational and experimental approaches for investigating nanoparticle-based drug delivery systems
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DOI：
10.1016/j.bbamem.2016.02.028
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发表时间：
2016-07-01
影响因子：
3.4
通讯作者：
Tieleman, D. P.
中科院分区：
文献类型：
--
作者：
Ramezanpour, M.;Leung, S. S. W.;Tieleman, D. P.
大多数治疗剂都存在溶解度差、从血流中快速清除、缺乏靶向性以及跨细胞膜易位能力差等问题。药物/基因递送系统 (DDS) 能够克服其中一些障碍，以增强药物递送至正确的作用部位，例如，癌细胞内部。在这篇综述中，我们重点关注作为 DDS 的纳米颗粒。互补的实验和计算研究增强了我们对纳米载体作用机制及其与药物、生物膜和其他生物分子的潜在相互作用的理解。我们回顾了 DDS 的关键生物物理方面，并讨论了计算机建模如何帮助合理设计具有改进和优化特性的 DDS。我们总结了 DDS 研究中常用的实验技术。然后，我们回顾了几类主要纳米载体的计算研究，包括树枝状聚合物和树枝状分子、聚合物、肽、核酸、脂质和碳基 DDS 以及金纳米粒子。本文是 J.C. Gumbart 和 Sergei Noskov 编辑的题为“膜蛋白”特刊的一部分。 (C) 2016 Elsevier B.V. 保留所有权利。
Most therapeutic agents suffer from poor solubility, rapid clearance from the blood stream, a lack of targeting, and often poor translocation ability across cell membranes. Drug/gene delivery systems (DDSs) are capable of overcoming some of these barriers to enhance delivery of drugs to their right place of action, e.g. inside cancer cells. In this review, we focus on nanoparticles as DDSs. Complementary experimental and computational studies have enhanced our understanding of the mechanism of action of nanocarriers and their underlying interactions with drugs, biomembranes and other biological molecules. We review key biophysical aspects of DDSs and discuss how computer modeling can assist in rational design of DDSs with improved and optimized properties. We summarize commonly used experimental techniques for the study of DDSs. Then we review computational studies for several major categories of nanocarriers, including dendrimers and dendrons, polymer-, peptide-, nucleic acid-, lipid-, and carbon-based DDSs, and gold nanoparticles. This article is part of a Special Issue entitled: Membrane Proteins edited by J.C. Gumbart and Sergei Noskov. (C) 2016 Elsevier B.V. All rights reserved.