The angiotensin converting enzyme (ACE)
The angiotensin converting enzyme (ACE)
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DOI：
10.1016/s1357-2725(02)00309-6
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发表时间：
2003-06-01
影响因子：
4
通讯作者：
Coates, D
中科院分区：
文献类型：
--
作者：
Coates, D
血管紧张素转换酶 1 广泛存在于整个动物界，是一种完整的膜结合蛋白，其活性位点指向细胞外空间。哺乳动物中表达两种亚型，一种是雄性生育所需的单结构域生发亚型，另一种是在肾素-血管紧张素系统中起关键作用的双结构域体细胞亚型。两个体细胞结构域均具有不同底物亲和力的活性。小鼠敲除实验以及与无脊椎动物同源物的比较工作表明，这两个结构域具有明显不同的作用。抑制血管紧张素转换酶的疗法的重要性是无可争议的，但我们现在正在通过基因组和比较生物学工具了解这些疗法如何以及为何发挥作用。 (C) 2003 Elsevier Science Ltd. 保留所有权利。
Angiotensin converting enzyme 1, found widely throughout the animal kingdom, is an integral membrane bound protein whose active sites are directed to the extracellular spaces. Two isoforms are expressed in mammals, a single domain germinal isoform required for male fertility, and a double domain somatic isoform which has a key role in the renin-angiotensin system. Both somatic domains are active with different substrate affinities. Mouse knockout experiments, and comparative work with invertebrate homologues, suggest that the two domains have clearly distinct roles. The importance of therapies involving inhibition of angiotensin converting enzyme are undisputed, but our understanding of how and why these therapies work is now being informed by the tools of genomic and comparative biology. (C) 2003 Elsevier Science Ltd. All rights reserved.