Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma
Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma
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DOI：
10.1111/j.1365-2141.2008.07077.x
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发表时间：
2008-06-01
影响因子：
6.5
通讯作者：
Harris, Adrian L.
中科院分区：
文献类型：
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作者：
Lawrie, Charles H.;Gal, Shira;Harris, Adrian L.
循环核酸已被证明具有作为癌症非侵入性诊断标记物的潜力。因此，我们通过比较弥漫性大B细胞淋巴瘤(DLBCL)患者(n=60)和健康对照组(n=43)血清中肿瘤相关MIRN155(miR-155)、MIRN210(miR-210)和MIRN21(miR-21)的水平来研究microRNAs是否也具有诊断价值。患者组明显高于对照组(P分别为0.009.0 2、0.0 2和0.0 4)。此外，MIRN21高表达与无复发生存率相关(P=0.05)。这是对循环microRNAs的第一次描述，并表明microRNAs有可能作为DLBCL和其他癌症的非侵入性诊断标记物。
Circulating nucleic acids have been shown to have potential as non-invasive diagnostic markers in cancer. We therefore investigated whether microRNAs also have diagnostic utility by comparing levels of tumour-associated MIRN155 (miR-155), MIRN210 (miR-210) and MIRN21 (miR-21) in serum from diffuse large B-cell lymphoma (DLBCL) patients (n = 60) with healthy controls (n = 43). Levels were higher in patient than control sera (P = 0.009, 0.02 and 0.04 respectively). Moreover, high MIRN21 expression was associated with relapse-free survival (P = 0.05). This is the first description of circulating microRNAs and suggests that microRNAs have potential as non-invasive diagnostic markers for DLBCL and possibly other cancers.