T-CELL RESPONSES TO MYELIN PROTEINS IN GUILLAIN-BARRE-SYNDROME
T-CELL RESPONSES TO MYELIN PROTEINS IN GUILLAIN-BARRE-SYNDROME
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DOI：
10.1016/0022-510x(92)90069-w
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发表时间：
1992-09-01
影响因子：
4.4
通讯作者：
GREGSON, N
中科院分区：
文献类型：
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作者：
KHALILISHIRAZI, A;HUGHES, RAC;GREGSON, N
我们已经调查的假设，格林-巴利综合征（GBS）的发病机制涉及自身免疫性T细胞对周围神经髓鞘P0和P2蛋白的反应。本文测定了GBS、慢性特发性脱髓鞘性多发性神经根神经病（CIDP）、正常对照（NC）和其他神经病（ONP）患者外周血单个核细胞（MNC）对髓鞘蛋白及其合成肽的增殖反应。19例GBS患者中有12例对P0或P2有反应，6例仅对P0及其肽有反应，3例仅对P2及其肽有反应，3例对P0和P2抗原都有反应。在CIDP患者中也发现对至少一种抗原的应答，但仅在NC和ONP中发现4/17和2/6。GBS的免疫应答是异质性的。本文首次描述的对P0蛋白的早期T细胞反应在某些病例的发病机制中可能是重要的。
We have investigated the hypothesis that the pathogenesis of Guillain-Barre syndrome (GBS) involves an autoimmune T cell response to P0 and P2 proteins of peripheral nerve myelin. The proliferative responses of blood mononuclear cells (MNC) to myelin proteins and synthetic peptides derived from them were determined in patients with GBS and chronic idiopathic demyelinating polyradiculoneuropathy (CIDP), normal controls (NC) and patients with other neuropathies (ONP). Twelve out of 19 GBS patients responded to P0 or P2, 6 to P0 and its peptides only, 3 to P2 and its peptides only, and 3 to both P0 and P2 antigens. Responses to at least one of the antigens were also found in 6/13 of CIDP patients, but in only 4/17 NC and 2/6 ONP. Immune responses in GBS are heterogeneous. The early T cell responses to P0 protein, described here for the first time, may be important in the pathogenesis of some cases.