Understanding the language of Lys36 methylation at histone H3.
Understanding the language of Lys36 methylation at histone H3.
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DOI：
10.1038/nrm3274
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发表时间：
2012-01-23
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组蛋白侧链在多个位点被翻译后修饰，包括在组蛋白H3(H3K36)上的Lys36处。酵母和人类的几种酶，包括甲基转移酶组含域2(Set2)和核受体组域1(NSD1)，分别改变了H3K36的甲基化状态，并在了解它们如何影响染色质结构和功能方面取得了重大进展。虽然H3K36甲基化通常与活性常染色质的转录有关，但它也参与了多种过程，包括选择性剪接、剂量补偿和转录抑制，以及DNA修复和重组。H3K36甲基化在染色质中的位置被破坏，可能导致一系列人类疾病，强调了这种修饰的重要性。
Histone side chains are post-translationally modified at multiple sites, including at Lys36 on histone H3 (H3K36). Several enzymes from yeast and humans, including the methyltransferases SET domain-containing 2 (Set2) and nuclear receptor SET domain- containing 1 (NSD1), respectively, alter the methylation status of H3K36, and significant progress has been made in understanding how they affect chromatin structure and function. Although H3K36 methylation is most commonly associated with the transcription of active euchromatin, it has also been implicated in diverse processes, including alternative splicing, dosage compensation and transcriptional repression, as well as DNA repair and recombination. Disrupted placement of methylated H3K36 within the chromatin landscape can lead to a range of human diseases, underscoring the importance of this modification.
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影响因子：
64.5
作者：
Alekseyenko AA;Peng S;Larschan E;Gorchakov AA;Lee OK;Kharchenko P;McGrath SD;Wang CI;Mardis ER;Park PJ;Kuroda MI
通讯作者：
Kuroda MI
影响因子：
3.7
作者：
Diehl F;Brown MA;van Amerongen MJ;Novoyatleva T;Wietelmann A;Harriss J;Ferrazzi F;Böttger T;Harvey RP;Tucker PW;Engel FB
通讯作者：
Engel FB
影响因子：
16.8
作者：
de Almeida, Sergio Fernandes;Grosso, Ana Rita;Carmo-Fonseca, Maria
通讯作者：
Carmo-Fonseca, Maria
影响因子：
4.8
作者：
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通讯作者：
Song, Ji-Joon
影响因子：
5.3
作者：
Bell, Oliver;Conrad, Thomas;Schuebeler, Dirk
通讯作者：
Schuebeler, Dirk