The Cooperative Prostate Cancer Tissue Resource:: A specimen and data resource for cancer researchers
The Cooperative Prostate Cancer Tissue Resource:: A specimen and data resource for cancer researchers
复制标题
DOI：
10.1158/1078-0432.ccr-04-0240
复制
发表时间：
2004-07-15
影响因子：
11.5
通讯作者：
Berman, JJ
中科院分区：
文献类型：
--
作者：
Melamed, J;Datta, MW;Berman, JJ
目的：合作前列腺癌组织资源(CPCTR)是美国国家癌症研究所支持的组织库，为研究人员提供大量具有临床注释的前列腺癌标本。本通讯向有意取得前列腺癌组织样本的研究人员介绍。实验设计：中心通过其四个参与机构，收集了1989年以来确诊的前列腺癌病例的标本和临床数据。这些标本包括前列腺癌根治术标本的石蜡切片和冰冻组织，以及前列腺针活检的石蜡切片。对所有病例进行标准化的组织病理学特征和临床数据提取。与前列腺癌相关的组织病理学、人口学(包括种族)、实验室数据(前列腺特异性抗原值)和临床结果的信息被输入所有病例的CPCTR数据库。CPCTR中的材料有多种组织形式，包括组织微阵列切片、石蜡包埋组织切片、血清和冰冻组织标本。根据CPCTR网站(www.prostateOrganes.org)上描述的申请程序，这些研究可用于研究目的。结果：CPCTR目前(截至2003年10月)包括5135例前列腺癌病例，其中4723例根治性前列腺癌切除术。冷冻组织，在某些情况下包括患者血清样本，可供1226例患者使用。生化复发数据可以识别残留病例、复发病例和无复发病例。结论：CPCTR提供了大量具有高度特征性的前列腺癌组织标本，包括组织芯片，以及相关的临床数据，用于生物标志物研究。鼓励有兴趣的调查人员申请使用这些材料(www.prostateOrganes.org)。
Purpose: The Cooperative Prostate Cancer Tissue Resource (CPCTR) is a National Cancer Institute-supported tissue bank that provides large numbers of clinically annotated prostate cancer specimens to investigators. This communication describes the CPCTR to investigators interested in obtaining prostate cancer tissue samples.Experimental Design: The CPCTR, through its four participating institutions, has collected specimens and clinical data for prostate cancer cases diagnosed from 1989 onward. These specimens include paraffin blocks and frozen tissue from radical prostatectomy specimens and paraffin blocks from prostate needle biopsies. Standardized histopathological characterization and clinical data extraction are performed for all cases. Information on histopathology, demography (including ethnicity), laboratory data (prostate-specific antigen values), and clinical outcome related to prostate cancer are entered into the CPCTR database for all cases. Materials in the CPCTR are available in multiple tissue formats, including tissue microarray sections, paraffin-embedded tissue sections, serum, and frozen tissue specimens. These are available for research purposes following an application process that is described on the CPCTR web site (www.prostatetissues.org).Results: The CPCTR currently (as of October 2003) contains 5135 prostate cancer cases including 4723 radical prostatectomy cases. Frozen tissues, in some instances including patient serum samples, are available for 1226 cases. Biochemical recurrence data allow identification of cases with residual disease, cases with recurrence, and recurrence-free cases.Conclusions: The CPCTR offers large numbers of highly characterized prostate cancer tissue specimens, including tissue microarrays, with associated clinical data for biomarker studies. Interested investigators are encouraged to apply for use of this material (www.prostatetissues.org).