Annexins and disease
Annexins and disease
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DOI：
10.1016/j.bbrc.2004.07.124
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发表时间：
2004-10-01
影响因子：
3.1
通讯作者：
Moss, SE
中科院分区：
文献类型：
--
作者：
Hayes, MJ;Moss, SE
膜联蛋白是一个在大多数真核生物中表达的密切相关的钙和膜结合蛋白家族。细胞类型。尽管它们的结构和生物化学相似性，膜联蛋白在细胞活动中具有不同的功能，包括囊泡运输、细胞分裂、凋亡、钙信号传导和生长调节。迄今为止，没有证据表明膜联蛋白家族的任何个体成员是致病基因，即，通过丢失、突变、易位或扩增导致已知人类疾病的基因。然而，有很好的证据表明，在某些临床条件下，膜联蛋白表达水平或定位的变化可能有助于疾病的病理后果和后遗症。通过这种方式，膜联蛋白与一些最严重的人类疾病类别间接相关，包括心血管疾病和癌症。在这篇综述中，我们考虑了膜联蛋白在疾病中所起的作用，并研究了可能导致疾病病理生理学的异常膜联蛋白行为的分子基础。(C)2004年爱思唯尔公司All rights reserved.
The annexins are a family of closely related calcium- and membrane-binding proteins expressed in most eukaryotic. cell types. Despite their structural and biochemical similarities annexins have diverse functions, in cellular activities that include vesicle trafficking, cell division, apoptosis, calcium signalling, and growth regulation. To date there is no evidence to suggest that any individual member of the annexin family is a disease-causing gene, i.e., a gene that through loss, mutation, translocation or amplification leads to a known human disease. However, there is good evidence that in certain clinical conditions, changes in annexin expression levels or localisation may contribute to the pathological consequences and sequelae of disease. In this way, annexins are indirectly linked to some of the most serious human disease classes including cardiovascular disease and cancer. In this review we consider the roles played by annexins in disease and examine the molecular basis for anomalous annexin behaviour that may contribute to disease pathophysiology. (C) 2004 Elsevier Inc. All rights reserved.