Periaortitis associated with anti-neutrophil cytoplasmic antibodies induced by bevacizumab combination therapy.
Periaortitis associated with anti-neutrophil cytoplasmic antibodies induced by bevacizumab combination therapy.
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与贝伐珠单抗联合治疗诱导的抗中性粒细胞胞浆抗体相关的动脉周围炎。
DOI：
10.2169/internalmedicine.52.6632
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发表时间：
2013
影响因子：
1.2
通讯作者：
Kouzo Yamada
中科院分区：
文献类型：
--
作者：
S. Murakami;H. Saito;M. Ohe;T. Kondo;F. Oshita;Kouzo Yamada
药物性脉管炎是化疗的一种罕见并发症。特别是，很少有研究药物引起的大血管炎的报道。我们在此报告一位57岁女性晚期肺腺癌患者，在贝伐单抗联合化疗后出现核周抗中性粒细胞胞质抗体(p-ANCA)阳性的主动脉炎。随着贝伐单抗联合治疗的增加，血管并发症的发生率可能会增加。化疗期间发生的非感染性发热可能是血管炎的征兆；因此，我们必须确保不能忽视可能的主动脉周围炎。
Drug-induced vessel vasculitis is a rare complication of chemotherapy. In particular, few reports have investigated drug-induced large vessel vasculitis. We herein report the case of a 57-year-old woman with advanced lung adenocarcinoma who developed perinuclear anti-neutrophil cytoplastic antibodies (p-ANCA)-positive periaortitis induced by bevacizumab combination chemotherapy. With the increasing use of combination therapy with bevacizumab, the incidence of vascular complications will potentially increase. A noninfectious fever occurring during chemotherapy might be a sign of vasculitis; therefore, we must ensure that possible periaortitis is not overlooked.