Effect of binge cocaine treatment on hindlimb vascular function.
Effect of binge cocaine treatment on hindlimb vascular function.
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暴饮可卡因治疗对后肢血管功能的影响。
DOI：
10.1002/jat.1083
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
Kadowitz,PhilipJ
中科院分区：
文献类型：
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作者：
Pradhan,Leena;Dabisch,PaulA;Liles,JohnT;Murthy,SN;Baber,SyedR;Simpson,ScottA;Agrawal,KrishnaC;Kadowitz,PhilipJ
已知长期滥用可卡因会导致内皮功能障碍和动脉粥样硬化。本研究调查了狂饮可卡因治疗（慢性可卡因滥用模型）对雄性斯普拉道利大鼠后肢血管床对肾上腺素能激动剂去甲肾上腺素、去氧肾上腺素和异丙肾上腺素、内皮依赖性血管舒张剂乙酰胆碱和内皮非依赖性血管舒张剂硝普钠 (SNP) 的血液反应的影响。大鼠接受单次暴食或两次暴食治疗。每次暴饮暴食治疗包括三剂可卡因（30 mg kg−1i.p.），持续 3 天。对于两次暴饮暴食治疗，两次暴饮暴食之间有 4 天的恢复期。治疗结束时，将大鼠麻醉，并通过左髂动脉中的导管将激动剂施用到右后肢循环中，并用右髂动脉周围的血流探针测量血流反应。与盐水对照组相比，接受双倍可卡因狂欢的大鼠表现出对去甲肾上腺素的血流反应的幅度和持续时间显着降低，对去氧肾上腺素、异丙肾上腺素和乙酰胆碱的血流反应的持续时间也显着降低。对 SNP 的血流反应没有改变。在接受两次可卡因狂欢的大鼠中，总血浆硝酸盐-亚硝酸盐水平显着降低，大内皮素水平显着升高。这项研究表明，暴饮可卡因治疗可以改变内皮功能，同时不改变平滑肌功能，并损害肾上腺素能通路。版权所有 © 2005 约翰·威利父子有限公司
Chronic cocaine abuse is known to cause endothelial dysfunction and atherosclerosis. The present study investigated the effect of binge cocaine treatment, a model for chronic cocaine abuse, on the blood ßow responses to the adrenergic agonists norepinephrine, phenylephrine and isoproterenol, the endothelium‐dependent vasodilator acetylcholine, and the endothelium independent vasodilator sodium nitroprusside (SNP) in the hindlimb vascular bed of male Sprague Dawley rats. Rats received either single binge or double binge treatment. Each binge treatment consisted of three doses of cocaine (30 mg kg−1i.p.) for 3 days. For double binge treatment, there was a 4 day recovery period between the binges. At the end of the treatment the rats were anesthetized and agonists were administered into the right hindlimb circulation through a catheter in the left iliac artery and blood ßow responses were measured with a ßow probe around the right iliac artery. Rats receiving double cocaine binges showed a significant decrease in the magnitude and duration of the blood ßow response to norepinephrine and a decrease in the duration of the blood ßow response to phenylephrine, isoproterenol and acetylcholine when compared with saline controls. The blood ßow response to SNP was not changed. Total plasma nitrate‐nitrite levels were significantly reduced and big endothelin levels were significantly increased in rats receiving double cocaine binges. This study demonstrates that binge cocaine treatment can alter endothelial function, while not changing smooth muscle function, and impairs the adrenergic pathway. Copyright © 2005 John Wiley & Sons, Ltd.