Differential expression of RANKL and osteoprotegerin in gingival crevicular fluid of patients with periodontitis
Differential expression of RANKL and osteoprotegerin in gingival crevicular fluid of patients with periodontitis
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DOI：
10.1177/154405910408300216
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发表时间：
2004-02-01
影响因子：
7.6
通讯作者：
Togari, A
中科院分区：
文献类型：
--
作者：
Mogi, M;Otogoto, J;Togari, A
NF-κ B配体受体激活因子（RANKL）在破骨细胞形成中起重要作用。最近的一项动物模型研究表明RANKL参与了这种牙周病的发病机制。然而，还没有人检测人类受试者体液中的RANKL水平。本通讯报告了重度、中度和轻度牙周病受试者龈沟液（GCF）中RANKL和RANKL诱饵受体骨保护素（OPG）的体内浓度。在牙周炎患者的GCF中检测到RANKL浓度升高和OPG浓度降低（*p < 0.05 vs.对照受试者）。牙周病患者龈沟液中RANKL与OPG浓度的比值显著高于健康受试者（*p < 0.01）。综上所述，这些数据表明RANKL和OPG有助于牙周病中的骨破坏。缩略语：GCF，龈沟液; IL，白细胞介素; OPG，骨保护素; RANK-L，NF-κ B配体受体激活剂。
The receptor activator for NF-kappaB ligand (RANKL) plays an important role in osteoclast formation. A recent study with animal models suggests the involvement of RANKL in the pathogenesis of this periodontal disease. However, no one has examined the level of RANKL in the body fluid of human subjects. This communication reports on the in vivo concentrations of RANKL and the RANKL decoy receptor osteoprotegerin (OPG) in the gingival crevicular fluid (GCF) of periodontal subjects with severe, moderate, and mild forms of the disease. An increased concentration of RANKL and a decreased concentration of OPG were detected in GCF from patients with periodontitis (*p < 0.05 vs. control subjects). The ratio of the concentration of RANKL to that of OPG in the GCF was significantly higher for periodontal disease patients than for healthy subjects (*p < 0.01). Taken together, these data suggest that RANKL and OPG contribute to osteoclastic bone destruction in periodontal disease. Abbreviations: GCF, gingival crevicular fluid; IL, interleukin; OPG, osteoprotegerin; RANK-L, receptor activator for NF-kappaB ligand.