Gut-directed hypnotherapy significantly augments clinical remission in quiescent ulcerative colitis.
Gut-directed hypnotherapy significantly augments clinical remission in quiescent ulcerative colitis.
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DOI：
10.1111/apt.12449
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发表时间：
2013-10
影响因子：
7.6
通讯作者：
Palsson OS
中科院分区：
文献类型：
--
作者：
Keefer L;Taft TH;Kiebles JL;Martinovich Z;Barrett TA;Palsson OS
Psychotherapy is not routinely recommended for in ulcerative colitis (UC). Gut-directed hypnotherapy (HYP) has been linked to improved function in the gastrointestinal tract and may operate through immune-mediated pathways in chronic diseases. To determine the feasibility and acceptability of hypnotherapy and estimate the impact of hypnotherapy on clinical remission status over a 1 year period in patients with an historical flare rate of 1.3 times per year. 54 patients were randomized at a single site to 7 sessions of gut-directed hypnotherapy (N = 26) or attention control (CON; N = 29) and followed for 1 year. The primary outcome was the proportion of participants in each condition that had remained clinically asymptomatic (clinical remission) through 52 weeks post-treatment. One-way ANOVA comparing hypnotherapy and control subjects on number of days to clinical relapse favored the hypnotherapy condition [F = 4.8 (1, 48), p = .03] by 78 days. Chi square analysis comparing the groups on proportion maintaining remission at 1 year was also significant [X2(1) = 3.9, p = .04], with 68% of hypnotherapy and 40% of control patients maintaining remission for 1 year. There were no significant differences between groups over time in quality of life, medication adherence, perceived stress or psychological factors. This is the first prospective study that has demonstrated a significant effect of a psychological intervention on prolonging clinical remission in patients with quiescent UC. Clinical Trial # NCT00798642
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DOI：
10.1097/00005176-199904001-00003
发表时间：
1999-04-01
影响因子：
2.9
作者：
Irvine, EJ
通讯作者：
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影响因子：
1.3
作者：
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Whorwell, PJ
影响因子：
1.3
作者：
Hammond, DC;Scheflin, AW;Vermetten, E
通讯作者：
Vermetten, E
影响因子：
3.3
作者：
Horton-Hausknecht, JR;Mitzdorf, U;Melchart, D
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