Stem Cell Plasticity in Mammals and Transdetermination in Drosophila: Common Themes?
Stem Cell Plasticity in Mammals and Transdetermination in Drosophila: Common Themes?
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DOI：
10.1634/stemcells.18-6-409
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发表时间：
2000-11
期刊：
影响因子：
5.2
通讯作者：
G. Wei;G. Schubiger;F. Harder;A. Müller
中科院分区：
文献类型：
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作者：
G. Wei;G. Schubiger;F. Harder;A. Müller
干细胞已经在许多哺乳动物组织中被发现（例如，骨髓、肌肉、肠道、皮肤和神经组织）。直到最近，人们普遍认为，哺乳动物体细胞干细胞的分化潜力仅限于一个组织，就像造血干细胞分化为造血细胞一样。从这个意义上说，体细胞干细胞的分化潜力是有限的。现在有几条证据对单边发展的观点提出了挑战。新的报告显示，哺乳动物体细胞干细胞可以在再生过程中重新填充异种细胞系统，因此具有令人惊讶的广泛分化潜力。因此，哺乳动物干细胞显然能够在干细胞系统之间改变命运，尽管导致这种改变的机制尚不清楚。
Stem cells have been identified in a number of mammalian tissues (e.g., bone marrow, muscle, gut, skin, and neural tissues). Until recently, it was generally believed that the differentiation potential of a mammalian somatic stem cell is restricted to one tissue only, as in the case of hematopoietic stem cells differentiating into hematopoietic cells. In this sense, somatic stem cells are limited in their differentiation potential. Several lines of evidence now challenge the idea of unilateral development. New reports show mammalian somatic stem cells can, in the course of regeneration, repopulate heterologous cell systems and therefore possess a surprisingly broad spectrum of differentiation potential. Thus, mammalian stem cells are apparently capable of fate changes between stem cell systems, although the mechanisms leading to such changes are unclear.