Surface carbohydrates involved in the adhesive interactions of metastatic cells.
Surface carbohydrates involved in the adhesive interactions of metastatic cells.
复制标题
表面碳水化合物参与转移细胞的粘附相互作用。
DOI：
10.1042/bst0250234
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发表时间：
1997
影响因子：
3.9
通讯作者：
J. Catterall
中科院分区：
文献类型：
--
作者：
G. Turner;J. Catterall
转移可以被定义为肿瘤细胞从身体的一个部位移动到另一个单独的部位，在那里它独立生长。这一过程是隐蔽的和渐进的，每个新的位点都是可能发生进一步转移的潜在位置。最终它会导致完全的不稳定，身体中所有的综合控制系统崩溃，甚至死亡。转移过程非常复杂，任何进展预测都取决于了解局部显微解剖学和微环境、所涉及的肿瘤细胞的性质以及肿瘤细胞最终接触的细胞外结构和细胞。因此，通过研究肿瘤细胞膜与外部环境的相互作用，有可能了解转移的重要步骤，并开发更有效的治疗干预手段。肿瘤细胞膜上装饰着许多碳水化合物分子
Introduction Metastasis can be defined as the movement of a tumour cell from one site in the body to another separate site, where it grows independently. This process is insidious and progressive, every new site being a potential location from which further metastasis can occur. Eventually it leads to total destabilization, collapse of all the integrated control systems in the body, and death. The metastatic process is very complex and any prediction of progress depends on knowing the local microanatomy and microenvironment, the properties of the tumour cell involved and the extracellular structures and cells with which the tumour cell finally makes contact. Thus, by studying the interactions of the tumour cell membrane with the external environment, it may be possible to understand important steps in metastasis, and develop more effective means of therapeutic intervention. The tumour cell membrane is decorated with many molecules that have carbohydrate