Photo-sonodynamic therapy mediated with OLI_NPs to induce HPV16E7-specific immune response and inhibit cervical cancer in a Tc-1-grafted murine model.
Photo-sonodynamic therapy mediated with OLI_NPs to induce HPV16E7-specific immune response and inhibit cervical cancer in a Tc-1-grafted murine model.
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DOI：
10.1016/j.jphotobiol.2022.112583
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发表时间：
2022-10
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通讯作者：
Guangzong Zhao;Shuning Chen;Jiao Zheng;Chenyang Li;Xiaowen Zhong;Yang Cao;Yue Zheng;Jiang-chuan Sun
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作者：
Guangzong Zhao;Shuning Chen;Jiao Zheng;Chenyang Li;Xiaowen Zhong;Yang Cao;Yue Zheng;Jiang-chuan Sun
宫颈癌是第四大常见妇科癌症。本文报道了载氧和脂多糖（LPS）/吲哚菁绿色（ICG）纳米粒（OLI_NPs）的合成，用于光声动力疗法（PSDT）介导的联合治疗，以诱导全身抗肿瘤免疫应答。我们有效地建立了一个新的纳米颗粒系统，一个多功能的纳米剂，集成了双模型成像和治疗肿瘤的能力。在这项研究中，我们证实了OLI_NPs可以作为一个多功能平台，不仅能够方便地诊断肿瘤，而且能够有效地提供原位肿瘤的治疗，允许同时进行双模成像和定位治疗，并结合PSDT介导的药物释放。此外，我们的联合策略可以通过诱导免疫原性细胞死亡（ICD）与包封的LPS的组合来有效地抑制肿瘤的发展并延长小鼠的寿命。总之，OLI_NPs与PSDT的联合治疗可以在常见的TC-1移植瘤模型中诱导抗肿瘤免疫应答和肿瘤抗原特异性免疫。因此，这种联合疗法是一种可行的宫颈癌治疗技术。
Cervical carcinoma is the fourth most common gynecological cancer. Here we reported the synthesis of oxygen-carried and lipopolysaccharide (LPS)/ indocyanine green (ICG)-loaded nanoparticles (OLI_NPs) for photo-sonodynamic therapy (PSDT) mediated combination therapy to induce systemic antitumor immune responses. We effectively built a new nanoparticle system, a multifunctional nanoagent that integrated the ability of dual-model imaging and therapy for tumors. In this study, we confirmed that OLI_NPs can act as a multifunctional platform that enables not only to diagnose tumors conveniently but also to efficiently provide treatment of in situ tumors, permitting simultaneous dual-mode imaging and localization of the therapy in combination with PSDT-mediated drug release. Furthermore, our combined strategy could effectively depress the tumor development and extend mouse life by the combination of inducing immunogenic cell death (ICD) with encapsulated LPS. In conclusion, combining therapy of OLI_NPs plus PSDT can induce anti-tumor immune responses and tumor antigen-specific immunity in a common TC-1 graft tumor model. Therefore, this combination therapy is a viable technique for cervical cancer treatment.