Paraseptal emphysema: Prevalence and distribution on CT and association with interstitial lung abnormalities.
Paraseptal emphysema: Prevalence and distribution on CT and association with interstitial lung abnormalities.
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DOI：
10.1016/j.ejrad.2015.03.010
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发表时间：
2015-07
影响因子：
3.3
通讯作者：
Hatabu, Hiroto
中科院分区：
文献类型：
--
作者：
Araki, Tetsuro;Nishino, Mizuki;Zazueta, Oscar E.;Gao, Wei;Dupuis, Josee;Okajima, Yuka;Latourelle, Jeanne C.;Rosas, Ivan O.;Murakami, Takamichi;O'Connor, George T.;Washko, George R.;Hunninghake, Gary M.;Hatabu, Hiroto
在心脏超声研究（FHS）人群中调查胸部CT图像上间隔旁肺气肿的患病率和分布，并评估其对肺功能的影响。还研究了与间质性肺异常的相关性。我们评估了2633名FHS参与者的胸部CT上的间隔旁肺气肿。参与者的特征，包括年龄，性别，吸烟状况，临床症状和肺功能测试的结果，进行了比较，与没有隔旁肺气肿。间隔旁肺气肿和间质性肺异常之间的关系进行了研究。在2633名参与者中，86名（3%）至少在一个肺区患有单纯的间隔旁肺气肿（定义为间隔旁肺气肿，除间隔旁肺气肿或极少数小叶中心肺气肿外，没有其他肺气肿亚型）。几乎总是累及肺的上部区域。与没有室间隔旁气肿的受试者相比，单纯室间隔旁气肿的受试者年龄明显更大，男性和吸烟者更多（平均64岁，71%男性，平均36包-年，p<0.001），FEV 1/FVC%（p=0.002）和一氧化碳弥散量（DLCO）（p=0.002）显著降低。单纯隔旁肺气肿和间质性肺异常之间存在显著相关性（p<0.001）。FHS人群中单纯间隔旁肺气肿的患病率为3%，主要影响上肺区，并导致肺功能下降。吸烟、年龄和男性是与隔旁肺气肿存在相关的因素。间隔旁肺气肿和间质性肺异常之间存在显著相关性。
To investigate the prevalence and distribution of paraseptal emphysema on chest CT images in the Framingham Heart Study (FHS) population, and assess its impact on pulmonary function. Also pursued was the association with interstitial lung abnormalities. We assessed 2633 participants in the FHS for paraseptal emphysema on chest CT. Characteristics of participants, including age, sex, smoking status, clinical symptoms, and results of pulmonary function tests, were compared between those with and without paraseptal emphysema. The association between paraseptal emphysema and interstitial lung abnormalities was investigated. Of the 2633 participants, 86 (3%) had pure paraseptal emphysema (defined as paraseptal emphysema with no other subtypes of emphysema other than paraseptal emphysema or a very few centrilobular emphysema involved) in at least one lung zone. The upper zone of the lungs was almost always involved. Compared to the participants without paraseptal emphysema, those with pure paraseptal emphysema were significantly older, and were more frequently male and smokers (mean 64 years, 71% male, mean 36 pack-years, p<0.001) and had significantly decreased FEV1/FVC% (p=0.002), and diffusion capacity of carbon monoxide (DLCO) (p=0.002). There was a significant association between pure paraseptal emphysema and interstitial lung abnormalities (p<0.001). The prevalence of pure paraseptal emphysema was 3% in the FHS population, predominantly affects the upper lung zone, and contributes to decreased pulmonary function. Cigarette smoking, aging, and male gender were the factors associated with the presence of paraseptal emphysema. Significant association between paraseptal emphysema and interstitial lung abnormalities was observed.
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影响因子：
3.3
作者：
Katzenstein, Anna-Luise A.;Mukhopadhyay, Sanjay;Dexter, Elizabeth
通讯作者：
Dexter, Elizabeth
DOI：
10.1056/nejmoa1216076
发表时间：
2013-06-06
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hunninghake GM;Hatabu H;Okajima Y;Gao W;Dupuis J;Latourelle JC;Nishino M;Araki T;Zazueta OE;Kurugol S;Ross JC;San José Estépar R;Murphy E;Steele MP;Loyd JE;Schwarz MI;Fingerlin TE;Rosas IO;Washko GR;O'Connor GT;Schwartz DA
通讯作者：
Schwartz DA
影响因子：
5
作者：
THURLBECK, WM;MULLER, NL
通讯作者：
MULLER, NL
DOI：
10.3109/15412551003631717
发表时间：
2010-04-01
影响因子：
2.2
作者：
Tsushima, Kenji;Sone, Shusuke;Fukuhara, Shunichi
通讯作者：
Fukuhara, Shunichi
影响因子：
5.9
作者：
Smith, Benjamin M.;Austin, John H. M.;Barr, R. Graham
通讯作者：
Barr, R. Graham