Increased brain-derived neurotrophic factor immunoreactivity in rat dorsal root ganglia and spinal cord following peripheral inflammation
Increased brain-derived neurotrophic factor immunoreactivity in rat dorsal root ganglia and spinal cord following peripheral inflammation
复制标题
DOI：
10.1016/s0006-8993(97)00597-0
复制
发表时间：
1997-08-01
期刊：
影响因子：
2.9
通讯作者：
Rush, RA
中科院分区：
文献类型：
--
作者：
Cho, HJ;Kim, JK;Rush, RA
我们最近的研究表明，外周炎症诱导脑源性神经营养因子（BDNF） mRNA的表达增加，这是由神经生长因子（NGF）在背根神经节（DRG）中介导的。在本研究中，我们采用免疫组织化学的方法评估了周围性炎症后DRG和脊髓中BDNF免疫反应性的变化。在大鼠脚掌足底注射弗氏佐剂引起外周组织炎症后，观察到L5 DRG中bdnf免疫反应性（IR）神经元谱的百分比显著增加，脊髓背角中BDNF-IR末端的表达显著升高。这些发现表明，外周组织炎症诱导DRG中BDNF合成增加，并增加BDNF向脊髓背角的顺行转运。本文简要讨论了BDNF增加的功能作用。(C) 1997爱思唯尔科学有限公司
Our recent study showed that peripheral inflammation induced an increased expression of brain-derived neurotrophic factor (BDNF) mRNA which was mediated by nerve growth factor (NGF) in the dorsal root ganglion (DRG). In the present study, we evaluated the change of BDNF immunoreactivity in the DRG and spinal cord following peripheral inflammation by means of immunohistochemistry. Significant increases in the percentage of BDNF-immunoreactive (IR) neuron profiles in the L5 DRG and marked elevation in the expression of BDNF-IR terminals in the spinal dorsal horn were observed following peripheral tissue inflammation produced by an intraplantar injection of Freund's adjuvant into the rat paws. These findings suggest that peripheral tissue inflammation induces an increased BDNF synthesis in the DRG and an elevated anterograde transport of BDNF to the spinal dorsal horn. The functional role of this increased BDNF was discussed briefly. (C) 1997 Elsevier Science B.V.